Juhua Zhuang*1, Saifei He*1, Guoyu Wang*, Guangdong Wang*†, Jing Ni*, Suiliang Zhang‡, Ying Ye*, Wei Xia*
Oncology Research, Vol.26, No.8, pp. 1257-1265, 2018, DOI:10.3727/096504018X15172756878992
Abstract Hepatocellular carcinoma (HCC) as one of the most refractory cancers leads to high mortality worldwide. Long
noncoding RNAs have been widely acknowledged as important biomarkers and therapeutic targets in HCC. In
this study, we investigated the effects of long noncoding RNA FGFR3-AS1 on tumor growth and metastasis in
HCC. First, we found that the expression of FGFR3-AS1 was upregulated about threefold in HCC samples and
cell lines. We knocked down FGFR3-AS1 in Huh7 and Hep3B cells and found that FGFR3-AS1 knockdown
significantly inhibited cell proliferation but induced apoptosis. Moreover, FGFR3-AS1 knockdown led to more
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