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    ARTICLE

    FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion

    Shuang Wang*, Daqi Zhao, Ruihua Tian*, Hailong Shi*, Xiangming Chen*, Wenzhi Liu*, Lin Wei*

    Oncology Research, Vol.23, No.4, pp. 197-203, 2015, DOI:10.3727/096504016X14537290676919

    Abstract Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancer; however, its function in gastric cancer remains unknown. In the current study, we showed that FGF19 is overexpressed in gastric cancer and is associated with depth of invasion, lymph node metastasis, and TNM stage. In addition, in vitro experiments demonstrated that More >

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