Chang Li^*, Shuohui Gao^*, Xiaoping Li^†, Chang Li^‡, Lianjun Ma^§

Oncology Research, Vol.28, No.6, pp. 675-679, 2020, DOI:10.3727/096504021X16137463165406

Abstract Colon cancer is one of the most lethal varieties of cancer. Chemotherapy remains as one of the principal treatment approaches for colon cancer. The anticancer activity of procaine (PCA), which is a local anesthetic drug, has been explored in different studies. In our study, we aimed to explore the anticancer effect of PCA on colon cancer and its underlying mechanism. The results showed that PCA significantly inhibited cell viability, increased the percentage of apoptotic cells, and decreased the expression level of RhoA in HCT116 cells in a dose-dependent manner (p < 0.05 or p < 0.01).… More >

Chang Li^*, Shuohui Gao^*, Xiaoping Li^†, Chang Li^‡, Lianjun Ma^§

Oncology Research, Vol.26, No.2, pp. 209-217, 2018, DOI:10.3727/096504017X14944585873622

Abstract Colon cancer is one of the most lethal varieties of cancer. Chemotherapy remains as one of the principal treatment approaches for colon cancer. The anticancer activity of procaine (PCA), which is a local anesthetic drug, has been explored in different studies. In our study, we aimed to explore the anticancer effect of PCA on colon cancer and its underlying mechanism. The results showed that PCA significantly inhibited cell viability, increased the percentage of apoptotic cells, and decreased the expression level of RhoA in HCT116 cells in a dose-dependent manner (p<0.05 or p<0.01). Moreover, PCA increased the… More >

Li Zhang^*, Hong-bin Duan^†, Yun-sheng Yang^*

Oncology Research, Vol.25, No.1, pp. 19-27, 2017, DOI:10.3727/096504016X14685034103914

Abstract Rap2B, a member of the Ras family of small GTP-binding proteins, was found to be highly expressed in various human tumors and plays an important role in the development of tumors. However, the function of Rap2B in hepatocellular carcinoma (HCC) remains unclear. Therefore, in this study, we investigated the biological functions of Rap2B in HCC and the potential underlying mechanisms. Our results indicated that Rap2B was highly expressed in HCC tissues and cell lines. Rap2B silencing obviously inhibited the proliferation, migration, and invasion of HCC cells, as well as attenuated xenografted tumor growth in vivo. More >