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    ARTICLE

    Membrane fluidity regulates high shear stress-induced FAK activation at different subcellular compartments

    FEI XIE1,2, BAOHONG ZHANG1,2, WENFENG XU1, XIAOLING LIAO1,*, QIUHONG HUANG1, BO LIU2,*

    BIOCELL, Vol.41, No.2-3, pp. 45-54, 2017, DOI:10.32604/biocell.2017.41.045

    Abstract Focal adhesion kinase (FAK) plays a vital role in mediating the adaptability of tumor cells under mechanical stimuli. Previous studies revealed that FAK can locate to different cell compartments, and its regulation is highly dependent on its subcellular localization. However, the local FAK activities and its regulation mechanism in different cell compartments of tumor cells in response to fluid shear stress are still unclear. In this study, 5 dyn/cm2 and 20 dyn/cm2 of shear stress was applied to HeLa cells for 30 min. The activities of FAK targeting different subcellular compartments (lipids rafts, non-rafts, focal adhesions… More >

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