Nahathai Dukaew*†, Teruaki Konishi‡§, Kongthawat Chairatvit¶, Narongchai Autsavapromporn#,
Noppamas Soonthornchareonnon**, Ariyaphong Wongnoppavich†
Oncology Research, Vol.28, No.2, pp. 161-175, 2020, DOI:10.3727/096504019X15736439848765
Abstract Radiotherapy (RT) is an important treatment for non-small cell lung cancer (NSCLC). However, the major
obstacles to successful RT include the low radiosensitivity of cancer cells and the restricted radiation dose,
which is given without damaging normal tissues. Therefore, the sensitizer that increases RT efficacy without
dose escalation will be beneficial for NSCLC treatment. Eurycomalactone (ECL), an active quassinoid isolated
from Eurycoma longifolia Jack, has been demonstrated to possess anticancer activity. In this study, we aimed
to investigate the effect of ECL on sensitizing NSCLC cells to X-radiation (X-ray) as well as the underlying
mechanisms. The… More >
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