Akinobu Furutani*†, Yoshihiro Sowa*, Hitoshi Fujiwara†, Eigo Otsuji†, Toshiyuki Sakai*
Oncology Research, Vol.23, No.1-2, pp. 87-87, 2015, DOI:10.3727/096504016X14514194509664
Abstract Histone deacetylase (HDAC) inhibitors have been shown to enhance the effects of 5-fluorouracil (5-FU)
against various cancer cells; however, no report has shown that an HDAC inhibitor may enhance the effects of
5-FU with radiation. Therefore, we investigated whether the novel HDAC inhibitor OBP-801/YM753 could
enhance the effects of 5-FU with radiation on esophageal squamous carcinoma KYSE170 cells. The inhibition
of the cell growth was significantly stronger with the combination of OBP-801/YM753 with 5-FU than with
the 5-FU treatment only. Furthermore, inhibition of the colony formation was the most effective with the combined treatment of More >
Login
Register
