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  • Open Access

    VIEWPOINT

    Galectins dysregulation: A way for cancer cells to invade and pervade

    MAHMOUD M. ABDELFATTAH1, REHAM HELWA1,2,*

    Oncology Research, Vol.30, No.3, pp. 129-135, 2022, DOI:10.32604/or.2022.026838

    Abstract Galectins are sticky molecules that bind to β-galactoside. Their interactions render them essential players in many cellular processes. The imbalance of galectin expression was reported in many diseases. In cancer, galectins interact with the extracellular matrix, evade the immune system, and potentially have broad interactions with blood components. In the last ten years, since 2010, we did focus on galectin research in different cancer types. Our findings showed an interaction between cancer cells and erythrocytes via galectin-4. Moreover, we found that upregulation of galectins was associated with lymph node metastasis in ovarian cancers. Hence, with this, we shortly review some… More >

  • Open Access

    ARTICLE

    Effect of Dextran 500 on Radial Migration of Erythrocytes in Postcapillary Venules at Low Flow Rates

    Sangho Kim∗,†, Peng Kai Ong*, Paul C. Johnson

    Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 83-92, 2009, DOI:10.3970/mcb.2009.006.083

    Abstract Recently, we reported that collision efficiency (fraction of total collisions that result in the formation of aggregates) between red blood cells was an important factor in the formation of aggregates in postcapillary venules. In the present study, we focus on how high molecular weight dextran influences the overall radial migration trend of red blood cells in the postcapillary venule along a longitudinal distance of 50 μm from the bifurcation which would in turn affect collision behavior of these cells. A radial migration index, which defines the extent of radial migration of individual cells relative to the vessel center, was found… More >

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