De-Zhong Zhang*, Bing-He Chen*, Lan-Fang Zhang†, Ming-Kun Cheng‡, Xiang-Jie Fang*, Xin-Jun Wu*
Oncology Research, Vol.25, No.9, pp. 1453-1462, 2017, DOI:10.3727/096504017X14886494526344
Abstract Gastric cancer (GC) is the most common epithelial malignancy worldwide. Basic transcription factor 3 (BTF3)
plays a crucial role in the regulation of various biological processes. We designed experiments to investigate the
molecular mechanism underlying the role of BTF3 in GC cell proliferation and metastasis. We confirmed that
BTF3 expression was decreased in GC tissues and several GC cell lines. Lentivirus-mediated downregulation
of BTF3 reduced cell proliferation, induced S and G2/M cell cycle arrest, and increased apoptosis. Knockdown
of BTF3 significantly reduced the expression of Forkhead box M1 (FOXM1). Upregulation of FOXM1 significantly inhibited the decrease… More >
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