Xin Shu, Qiang Wang*, Qingming Wu*
Oncologie, Vol.24, No.3, pp. 427-439, 2022, DOI:10.32604/oncologie.2022.023248
- 19 September 2022
Abstract Liver cancer is ranked as the second leading cause of cancer-related death across the world, and hepatocellular
carcinoma (HCC) comprises nearly 90% of all primary liver cancer cases. However, until now, the pathological
mechanisms underlying HCC oncogenesis and development remains largely unclear. Eph receptors and their
ephrin ligands (Eph/Ephrin system) are involved in various physiological process, such as embryogenesis, neuronal migration, immune response and vascular development. Recently, emerging evidence has showed that the
Eph/Ephrin system also plays an essential role in initiation and development of multiple types of cancer, including
liver cancer. The Eph/Ephrin system More >
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