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    REVIEW

    Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury

    RAMSHA SHAMS1,2, NAREN L. BANIK1,2,3,*, AZIZUL HAQUE1,*

    BIOCELL, Vol.45, No.6, pp. 1453-1457, 2021, DOI:10.32604/biocell.2021.017659

    Abstract Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent in the US, no FDA-approved therapy exists due to the unfortunate complexity of the condition, and the difficulties of SCI may be furthered by the development of SCI-related complications, such as osteoporosis. SCI demonstrates two crucial stages for consideration: the primary stage and the secondary stage. While the primary stage is suggested to be immediate and irreversible, the secondary stage is proposed as a promising window of opportunity for therapeutic intervention. Enolase, a metabolic… More >

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