Yi Jin¹, Zexing Shan², Fan Yang¹, Xinwen Fan¹, Jie Lin³, Zeqing Huang^1,*, Xudong Zhu^3,4,*

Oncology Research, Vol.33, No.10, pp. 2937-2960, 2025, DOI:10.32604/or.2025.062250 - 26 September 2025

Abstract Background: As a major histopathological subtype of gastric cancer (GC), stomach adenocarcinoma (STAD) is an important malignant tumor in the digestive system. Increasing evidence also indicates that endoplasmic reticulum (ER) stress plays a pivotal role in the pathogenesis and progression of GC. Therefore, this study aims to screen and identify vital ER stress-related genes that could contribute to the malignant development and poor prognosis for STAD. Methods: A novel ER stress-related risk score signature was developed employing machine learning techniques. Then, a prognostic prediction nomogram was also built based on the clinicopathological characteristics and the… More > Graphic Abstract

MINGZHI LUO^#,*, CHANGYU SUN^#, JIA GUO, XIANGRONG ZHANG, JING ZHANG, XUANYU SHI, LEI LIU, YAN PAN, JINGJING LI, LINHONG DENG^*

BIOCELL, Vol.49, No.5, pp. 833-855, 2025, DOI:10.32604/biocell.2025.063869 - 27 May 2025

Abstract Background: Mechanical ventilation (MV) provides life support for patients with severe respiratory distress but can simultaneously cause ventilator-induced lung injury (VILI). However, due to a poor understanding of its mechanism, there is still a lack of effective remedies for the often-deadly VILI. Recent studies indicate that the stretch associated with MV can enhance the secretion of extracellular vesicles (EVs) and induce endoplasmic reticulum (ER) stress in airway smooth muscle cells (ASMCs), both of which can contribute to VILI. But whether MV-associated stretch enhances the secretion of EVs via ER stress in ASMCs as an underlying… More > Graphic Abstract

XIAODAN SONG^1,#, YUQING WANG^1,#, XIUMEI CHENG^2,3,*, XIAOYUN ZHANG², DI WANG⁴, YANQING REN⁵, XINHUA LI⁴, XIAOQIAN DI¹, SISI XUE², TIANYUAN LV¹

BIOCELL, Vol.48, No.12, pp. 1761-1772, 2024, DOI:10.32604/biocell.2024.057203 - 30 December 2024

Abstract Background: Prior research has established that exposure to low temperatures adversely affects ovarian function, yet the precise mechanisms remain to be elucidated. Methods: Thirty experimental rats, each demonstrating two regular estrous cycles, were assorted randomly into three distinct groups: a control group, a cold exposure group, and a group treated with 4-phenylbutyric acid (4-PBA). To mimic the conditions of cold exposure, rats in the cold exposure and 4-PBA groups were subjected to immersion in ice water for 21 days. After 7 days of exposure to ice water, the 4-PBA group received intraperitoneal injections of a… More >

SIYUAN LIU, YUAN ZHAO, YU YU, DOU YE, QIAN WANG, ZHAOYAN WANG, ZUO LUAN^*

BIOCELL, Vol.48, No.7, pp. 1115-1126, 2024, DOI:10.32604/biocell.2024.050493 - 03 July 2024

Abstract Introduction: Transplantation of mesenchymal stromal cells (MSCs) is a promising therapy for type 1 diabetes (T1D). However, whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response in β cells remains unclear. Methods: To investigate this, we induced early-onset T1D in non-obese diabetic mice using streptozotocin. Subsequently, T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline. We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels, body weight, histopathology, pancreatic protein expression, and serum levels of cytokines, proinsulin, and C-peptide. Results: Infused MSCs… More > Graphic Abstract

YIFAN LI^1,2, JING ZHANG¹, YITAO FAN¹, HANDAN XIAO¹, KEXIN KANG¹, YALI ZHOU¹, ZHIWEN ZHANG^3,*, YUMIN LI¹, MUZHOU TENG^1,*

BIOCELL, Vol.47, No.8, pp. 1783-1791, 2023, DOI:10.32604/biocell.2023.028056 - 28 August 2023

Abstract Background: ((1-triphenylaminebenzo[c][1,2,5] thiadiazole-4-yl) styryl)-1-methylpyridin methylpyridin-1-ium iodide salt (TBZPy) is a novel photosensitizer that displays excellent photodynamic properties. However, There are few reports on the mechanism of action of the TBZPy photodynamic. Previous studies revealed that photodynamic therapy (PDT) could induce endoplasmic reticulum stress by acting on the endoplasmic reticulum. Therefore, in this study, we investigated the effects of endoplasmic reticulum stress induced by TBZPy-PDT in treating High-risk human papillomavirus (HR-HPV) infection and their underlying mechanisms. Methods: The human cervical cancer cell line HeLa (containing whole genome of HR-HPV18) was treated with TBZPy-PDT. Cell migration, invasion,… More > Graphic Abstract

XIRU XU^1,#, YUAN FANG^1,#, BIAO ZHANG^1,*, SHICHAO TENG¹, XIANG WU¹, JING ZHANG¹, XIAOQUN GU², MEIXIA MA³

BIOCELL, Vol.47, No.7, pp. 1595-1609, 2023, DOI:10.32604/biocell.2023.027697 - 21 June 2023

Abstract Background: While the Bushen Yizhi Formula can treat Alzheimer’s disease (AD), the yet to be ascertained specific mechanism of action was explored in this work. Methods: Different concentrations of the Bushen Yizhi Formula and amyloid-beta peptide (Aβ) were used to treat rat pheochromocytoma cells (P12) and human neuroblastoma cells (SH-SY5Y). Cell morphological changes were observed to determine the in vitro cell damage. Cell Counting Kit (CCK)-8 assay and flow cytometry were employed to identify cell viability and apoptosis/cell cycle, respectively. Western blotting and immunohistochemistry were employed to measure the expressions of endoplasmic reticulum stress (ERS)-related proteins (GRP78… More >

YONGKANG SHI, JUN MA, KE CHEN, BIN CHEN^*

Oncology Research, Vol.30, No.4, pp. 201-210, 2022, DOI:10.32604/or.2022.027584 - 31 January 2023

Abstract 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for various cancers. However, the drug resistance developed by tumor cells hinders the therapeutic effect. Konjac glucomannan (KGM) is indicated to sensitize 5-FU-resistant hepatocellular carcinoma (HCC) cells to 5-FU. In our study, we found that KGM or 5-FU treatment alone did not affect the malignant cell behaviors and endoplasmic reticulum (ER) stress of 5-FU-resistant HCC cells or HepG2/5-FU and Bel-7402/5-FU cells, while cotreatment with KGM and 5-FU significantly facilitated HCC cell apoptosis and ER stress and suppressed cell proliferation potential and migration abilities. Moreover, we explored the… More >

XINFU FAN^1,2,#, JIE CHEN^3,#, ZONGMENG ZHANG^4,#, FANGHUI CHEN⁵, HAOSEN WANG⁶, YAFEI CAI⁶, JUN LI^7,*

BIOCELL, Vol.46, No.6, pp. 1527-1535, 2022, DOI:10.32604/biocell.2022.018269 - 07 February 2022

Abstract Spinal cord injury (SCI) remains an intractable clinical challenge of neurosurgery, it can be divided into two stages: uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death. The apoptosis was the one of most important events in secondary injury, previous studies revealed that excessive endoplasmic reticulum (ER) stress breaks down the homeostasis and triggers apoptosis in the spinal cord. To deter or alleviate the secondary jury, we screen one of fat-soluble compounds, salubrinal, which was an inhibitor of eIF2α dephosphorylation can repair SCI by inhibiting ER stress in… More >

XIANGCAI YANG¹, JIAGUI QU², JIEJING LI^1,*

BIOCELL, Vol.46, No.4, pp. 1041-1051, 2022, DOI:10.32604/biocell.2022.017383 - 15 December 2021

Abstract Malignant glioma is one of the most common and deadly tumors in the central nervous system while developing effective treatments for this devastating disease remains a challenge. Previously, we demonstrated that the vitamin nicotinic acid (NA) inhibits glioma invasion. Here, we show that high-dose NA induces apoptosis of malignant glioma cells in vitro and in vivo. In cultured U251 glioma cells treated with NA, we detected ER stress that was likely caused by elevated intracellular calcium levels. The elevated calcium can be attributed to the activation of TRPV1, a cation channel that has been implicated in cutaneous More >

JINYONG HUANG¹, TIANMING TENG¹, BO BIAN¹, YUCHEN XUE¹, LONGFEI HUANG¹, ZHELONG XU², QING YANG^1,*, YUEMIN SUN^1,*

BIOCELL, Vol.46, No.3, pp. 667-675, 2022, DOI:10.32604/biocell.2021.015917 - 18 November 2021

Abstract Zinc is a trace element involved in maintaining cellular structure and function. Although zinc is associated with left ventricular hypertrophy (LVH), there have been few reports on this association. This study aimed to evaluate the correlation between Zip14 and expression of endoplasmic reticulum stress (ERS) associated molecules in hypertrophied hearts of rats. Dahl salt-sensitive rats were fed a high salt diet to establish a left ventricular hypertrophy (LVH) rat model. RT-PCR was used to determine Zip14, activating transcription factor (ATF4), ATF6, x-box-binding protein 1 (xBP1), C/EBP homologous protein (CHOP), immunoglobulin-binding protein (BiP) mRNA expression. Western… More >