Yan Zhang, Gang Cao, Qing-gong Yuan, Jun-hui Li, Wen-Bin Yang
Oncology Research, Vol.25, No.4, pp. 537-544, 2017, DOI:10.3727/096504016X14756640150695
Abstract Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential
role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer
(CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in CRC.
Our results demonstrated that the expression of EMX2 was greatly decreased in CRC tissues and cell lines.
Overexpression of EMX2 significantly inhibited the proliferation in vitro and CRC tumor growth in nude mice.
In addition, EMX2 also inhibited the migration and invasion More >
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