Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Hafida Khelafi¹, Wassima Lakhdari², Mustapha Mounir Bouhenna³, Said Boudeffeur⁴, Hayet Meamiche¹, Salah Neghmouche Nacer^5,*, Meriam Laouar⁶

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3975-3989, 2025, DOI:10.32604/phyton.2025.073210 - 29 December 2025

Abstract Essential oils (EOs) derived from medicinal plants are gaining recognition as sustainable alternatives to synthetic fungicides in the management of plant pathogens. This study investigates the chemical composition, chromatographic profile, and antifungal of Mentha rotundifolia essential oil against Fusarium oxysporum f. sp. albedinis (Foa), the pathogen responsible for Bayoud disease in date palm. The oil was extracted through hydrodistillation and characterized using thin-layer chromatography (TLC) and gas chromatography–mass spectrometry (GC-MS), revealing multiple fractions corresponding to terpenoid constituents and 23 chemical constituents, predominantly oxygenated monoterpenes (68.51%), with piperitenone oxide as the major component (62.53%). The antifungal efficacy was evaluated… More >

Xiaolong Li, Hui Chen, Yingwen Liu, Peng Yang^*

Frontiers in Heat and Mass Transfer, Vol.23, No.6, pp. 1767-1788, 2025, DOI:10.32604/fhmt.2025.070537 - 31 December 2025

Abstract Hazardous gas intrusion in tightly sealed and geometrically complex confined spaces, such as armored tanks, poses a critical threat to occupant health. The intricate internal structure of these systems may lead to non-intuitive pollutant transport pathways. However, the spatial and temporal evolution of these structures, as well as the intrinsic mechanisms of the purification systems, remain poorly elucidated. In this study, a high-fidelity, transient three-dimensional computational fluid dynamics (CFD) model was developed to simulate the leakage and dispersion of carbon monoxide (CO) and nitrogen dioxide (NO₂) using the RNG k-ε turbulence model. Scenarios with and without… More > Graphic Abstract

Zhenhong Wang^1,2, Hailong Wu^3,*

Journal of Psychology in Africa, Vol.35, No.6, pp. 863-869, 2025, DOI:10.32604/jpa.2025.073522 - 30 December 2025

Abstract We examined the direct relationship between childhood emotional abuse and depression in adolescents and the mediating roles of resilience and self-efficacy in that relationship. Using a cross-sectional study design, 636 Chinese adolescents (Girls = 48.6%, mean years of service = 15.8, SD = 1.9) completed the Childhood Trauma Questionnaire (CTQ), the Ego-Resiliency Scale (ERS), the General Self-Efficacy Scale (GSES), and the Patient Health Questionnaire-9 (PHQ-9). Mediation analysis revealed that childhood emotional abuse significantly predicted higher levels of depression. Moreover, resilience and self-efficacy were found to mediate this relationship both independently and sequentially. Specifically, resilience accounted More >

Fan Deng^*

Journal of Psychology in Africa, Vol.35, No.6, pp. 797-805, 2025, DOI:10.32604/jpa.2025.068735 - 30 December 2025

Abstract This study investigated the relationship between customer-employee exchange (CEX) and employee work engagement (vigor, dedication, absorption), and the role of psychological safety and self-efficacy mediate that relationship. Survey data were collected from 329 Chinese hotel employees (females = 52.9%, tenure: 1–3 years = 50.5%). The results following ordinary least squares regression and the SPSS PROCESS macro indicate that higher customer-employee exchange is associated with employee vigor, dedication, and absorption. Psychological safety and self-efficacy mediate the relationship between customer-employee exchange and vigor and dedication to be stronger, while the work absorption mediating effect is not significant. More >

MD Hamid Borkot Tulla^1,*, MD Moniur Rahman Ratan², Rashid MD Mamunur³, Abdullah Hil Safi Sohan⁴, MD Matiur Rahman⁵

Journal of Cyber Security, Vol.7, pp. 675-691, 2025, DOI:10.32604/jcs.2025.074737 - 24 December 2025

Abstract Phishing is considered one of the most widespread cybercrimes due to the fact that it combines both technical and human vulnerabilities with the intention of stealing sensitive information. Traditional blacklist and heuristic-based defenses fail to detect such emerging attack patterns; hence, intelligent and transparent detection systems are needed. This paper proposes an explainable machine learning framework that integrates predictive performance with regulatory accountability. Four models were trained and tested on a balanced dataset of 10,000 URLs, comprising 5000 phishing and 5000 legitimate samples, each characterized by 48 lexical and content-based features: Decision Tree, XGBoost, Logistic… More >

Chang-Eui Hong^1,2,3, Su-Yun Lyu^1,2,3,*

BIOCELL, Vol.49, No.12, pp. 2377-2397, 2025, DOI:10.32604/biocell.2025.072360 - 24 December 2025

Abstract Objective: Triple-negative breast cancer (TNBC) remains a major therapeutic challenge with limited treatment options and poor prognosis. This study aimed to investigate the synergistic anticancer effects of doxorubicin (DOX) combined with Viscum album L. var. coloratum agglutinin (VCA) and to elucidate the underlying molecular mechanisms in TNBC cells. Methods: This study evaluated the synergistic effects and mechanisms of doxorubicin (DOX) and Viscum album L. var. coloratum agglutinin (VCA) combination in MDA-MB231 TNBC cells. Cell viability, oxidative stress markers, apoptosis-related proteins, cell migration, and proliferative recovery were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, superoxide dismutase (SOD) and nitric oxide… More >

Yousra Hammouti^1,2,*, François Mesnard², Oussama Khibech³, Mohamed Taibi¹, Yousra Belbachir³, El Hassania Loukili⁴, Reda Bellaouchi⁵, Abdeslam Asehraou⁵, Mohamed Addi^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3563-3583, 2025, DOI:10.32604/phyton.2025.071139 - 01 December 2025

Abstract Centaurium erythraea Rafn (“Gosset El Haya”) has long been prized in North African folk medicine, yet Moroccan chemobiological data remain scarce. Ethanol extracts of northern Moroccan aerial parts were profiled by high-performance liquid chromatography (HPLC) and found rich in phenolics, dominated by 4-hydroxybenzoic acid (57.8%) and naringin (10.3%). The extract exhibited strong antioxidant power in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, with a half-maximal inhibitory concentration (IC₅₀) of ≈74 µg mL⁻¹, and a total antioxidant capacity (TAC) of ≈201 µg mL⁻¹ and selective antimicrobial activity, sharply inhibiting Aspergillus niger, Penicillium digitatum, and Rhodotorula glutinis while sparing Staphylococcus aureus. In-silico absorption, distribution, metabolism,… More >

Yezi Zeng^1,*, Yufei Cong²

International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1663-1679, 2025, DOI:10.32604/ijmhp.2025.072125 - 28 November 2025

Abstract Background: Academic stress is a critical factor influencing university students’ well-being. However, research has shown that stress is not a unidimensional construct; different types of stressors (challenge vs. hindrance) may lead to distinct outcomes. This study constructed a structural equation model (SEM) to examine the relationships between challenge and hindrance academic stressors and students’ well-being, as well as the mediating mechanisms. Methods: Data were collected from 836 undergraduates at six universities in China (58.4% female, 41.6% male; Mean age = 20.47 ± 1.46 years). Descriptive statistics, Pearson correlations, and SEM with 5000 bootstrap resamples were conducted… More >

Rym Akrout¹, Ludovic Leloup², Khouloud Ayed¹, Fabrice Parat², Sami Zekri^3,4, Wassim Y. Almawi¹, Rahma Boughriba¹, Hanen Attia¹, Olfa Masmoudi-Kouki⁴, Hervé Kovacic^2,*, Asma Gati^1,*

Oncology Research, Vol.33, No.12, pp. 3887-3906, 2025, DOI:10.32604/or.2025.070729 - 27 November 2025

Abstract Objectives: Cisplatin (CDDP) therapy for glioblastoma (GBM) is linked with several limitations, which include poor penetration of the blood-brain barrier (BBB), systemic toxicity, and the development of drug resistance mechanisms implicating oxidative stress dysregulation and compromised apoptotic pathways. This study evaluates C-Phycocyanin (C-PC) as a potential adjuvant to enhance CDDP efficacy by modulating redox balance and apoptosis. Methods: GBM cells (U87 and U87-EGFRvIII) were treated with CDDP, C-PC, or their combination. Cell viability was assessed by MTT assay; apoptosis was evaluated by DAPI staining and Western blot analysis of cleaved Caspase-3 and poly (ADP-ribose) polymerase… More > Graphic Abstract