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  • Open Access

    ARTICLE

    Chitosan/PVA Films and Silver Nanoparticle Impregnated Nanofibrous Dressings for Evaluation of their Wound Healing Efficacy in Wistar Albino Rat Model

    SOBHA KOTA*, RATNAKUMARI ANANTHA, VAYUNANDANA RAO GOVADA, PRADEEP DUMPALA

    Journal of Polymer Materials, Vol.40, No.3-4, pp. 285-303, 2023, DOI:10.32381/JPM.2023.40.3-4.10

    Abstract The exoskeleton of marine shrimp contains a natural, biocompatible polymer chitin, which is dumped as a waste. The study proposes the sustainable single-pot-extraction of chitosan from the waste and its use in the fabrication of wound-dressings, and thus leverage its piezoelectric, antioxidant, hypoglycaemic and medicinal properties in wound-healing. The Fourier transform infrared spectrum revealed that marine chitosan contains functional groups with N-O, O-H, and CO stretching. Scanning electron micrographs demonstrated the spherical and mesoporous structures of the extracted chitosan. X-ray diffraction analysis showed a semi-crystalline phase of chitosan particles with a mean size of 28.9 nm. The film prepared with… More >

  • Open Access

    ARTICLE

    Toughening of Unsaturated Polyester Resin by Blending with Polyether Telechelics. Dependency of Toughening Efficacy on End Groups

    JEEMOL. P. A1, SURESH MATHEW1, REGHUNADHAN NAIR C.P.2,*

    Journal of Polymer Materials, Vol.39, No.1-2, pp. 111-120, 2022, DOI:10.32381/JPM.2022.39.1-2.7

    Abstract Polyether telechelics based on ethylene glycol,1,2-propylene glycol and 1,4- butylene glycol of with various molar masses and bearing at both terminals functional groups such as maleimide, itaconimide, nadimide and hydroxyl groups were individually examined as toughening agents for an unsaturated polyester resin (UPER). For a given telechelic, the toughening effect was evaluated at different mass ratios. The difference in toughening efficacy arose from the differential reactivity of the telechelics end groups combined with the unsaturation of the UPER with the reactive diluent, styrene. This causes a differential distribution of the polyether groups in the UPER matrices, resulting in a differential… More >

  • Open Access

    ARTICLE

    Gamma Radiation Induced Mutual Grafting of Quaternary Ammonium-Based Monomer on to Rayon Fibers to Improve its Water Absorbency and Antibacterial Efficacy

    SUBRATA PAL1,2, BHUVNESHWAR RAI1, AJAY KUMAR TYAGI1, SUNITA RATTAN2, VIRENDRA KUMAR3

    Journal of Polymer Materials, Vol.39, No.1-2, pp. 55-70, 2022, DOI:10.32381/JPM.2022.39.1-2.4

    Abstract The present work is focused on the study of antimicrobial and water absorption properties of the surface of grafted rayon fiber with quaternary ammonium-based salts containing 3- Acrylamidopropyl trimethyl ammonium chloride (APTAC) monomer induced by gamma radiation. Grafting was qualitatively confirmed by FTIR-ATR,TGA, SEM and by calculating grafting yield and grafting efficiency. The performance was examined for water absorbency and antibacterial efficacy (R) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Study showed that water absorption, grafting yield and grafting efficiency increased steadily with the increase in monomer concentration and absorbed gamma irradiation dose up to a certain… More >

  • Open Access

    ARTICLE

    Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

    HUAN GAO1,2, JIE ZHANG1, TONY G. KLEIJN1,3,4, ZHAOYONG WU5, BING LIU1,6, YUJIN MA6, BAOYUE DING1,*, DONGFENG YIN2,*

    Oncology Research, Vol.32, No.4, pp. 769-784, 2024, DOI:10.32604/or.2023.044276

    Abstract Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival. The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect. To improve the treatment efficacy, we developed Pluronic P123 (P123)-based polymeric micelles dually decorated with alendronate (ALN) and cancer-specific phage protein DMPGTVLP (DP-8) for targeted drug delivery to breast cancer bone metastases. Doxorubicin (DOX) was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity (3.44%). The DOX-loaded polymeric micelles were spherical,… More > Graphic Abstract

    Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

  • Open Access

    ARTICLE

    Evaluating the Efficacy of Latent Variables in Mitigating Data Poisoning Attacks in the Context of Bayesian Networks: An Empirical Study

    Shahad Alzahrani1, Hatim Alsuwat2, Emad Alsuwat3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1635-1654, 2024, DOI:10.32604/cmes.2023.044718

    Abstract Bayesian networks are a powerful class of graphical decision models used to represent causal relationships among variables. However, the reliability and integrity of learned Bayesian network models are highly dependent on the quality of incoming data streams. One of the primary challenges with Bayesian networks is their vulnerability to adversarial data poisoning attacks, wherein malicious data is injected into the training dataset to negatively influence the Bayesian network models and impair their performance. In this research paper, we propose an efficient framework for detecting data poisoning attacks against Bayesian network structure learning algorithms. Our framework utilizes latent variables to quantify… More >

  • Open Access

    ARTICLE

    A Model for Predicting the Psychological Well-Being of Older Adults in South Korea

    Hyangjin Park1, Haeryun Cho2, So Yeon Yoo3,*

    International Journal of Mental Health Promotion, Vol.25, No.11, pp. 1219-1228, 2023, DOI:10.32604/ijmhp.2023.041490

    Abstract This study examined factors related to the psychological well-being of older adults and built and verified a model for predicting psychological well-being. The participants were 350 older adults aged over 60 years who lived in South Korea and were active in the local community. The model proposed in this study was found to be suitable. Depression, self-efficacy, and social support had a direct effect on the psychological well-being of older adults, while depression, activities of daily living (ADLs), and self-efficacy had an indirect effect. Self-efficacy and social support mediated the relationship between depression and psychological well-being, and self-efficacy mediated the… More >

  • Open Access

    ARTICLE

    Assessing the Efficacy of Improved Learning in Hourly Global Irradiance Prediction

    Abdennasser Dahmani1, Yamina Ammi2, Nadjem Bailek3,4,*, Alban Kuriqi5,6, Nadhir Al-Ansari7,*, Salah Hanini2, Ilhami Colak8, Laith Abualigah9,10,11,12,13,14, El-Sayed M. El-kenawy15

    CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 2579-2594, 2023, DOI:10.32604/cmc.2023.040625

    Abstract Increasing global energy consumption has become an urgent problem as natural energy sources such as oil, gas, and uranium are rapidly running out. Research into renewable energy sources such as solar energy is being pursued to counter this. Solar energy is one of the most promising renewable energy sources, as it has the potential to meet the world’s energy needs indefinitely. This study aims to develop and evaluate artificial intelligence (AI) models for predicting hourly global irradiation. The hyperparameters were optimized using the Broyden-Fletcher-Goldfarb-Shanno (BFGS) quasi-Newton training algorithm and STATISTICA software. Data from two stations in Algeria with different climatic… More >

  • Open Access

    ARTICLE

    Implementation of Psychosocial Intervention StomieCare for Patients with Rectal Cancer Treated by Rectal Excision and Temporary Stoma: A Pilot Study of Feasibility, Acceptability and Efficacy

    Implémentation d’une intervention psychosociale StomieCare auprès de patients opérés d’un cancer du rectum avec stomie temporaire : une étude pilote de faisabilité, d’acceptabilité et d’efficacité

    Stéphane Faury1,*, Katia M’Bailara1,2, Eric Rullier3, Quentin Denost4, Bruno Quintard1

    Psycho-Oncologie, Vol.17, No.3, pp. 147-157, 2023, DOI:10.32604/po.2023.044901

    Abstract Objective: This study aims to evaluate the feasibility, acceptability, and efficacy of StomieCare for rectal cancer patients undergoing surgery with a temporary stoma. StomieCare (three individual sessions) comprises thematic discussions, information and education, and teaching problem-solving and cognitive restructuring. Methods: Thirty-seven rectal cancer participants treated by surgery and temporary stoma were recruited and randomized to control (routine care approach, n = 20) and intervention (routine care and StomieCare, n = 17) groups. Outcomes were psychological distress (anxiety and depression, HADS), body image (BIS, ESS), and quality of life (FACT-C), at one week before surgery (T1) and 3 months after stoma… More >

  • Open Access

    ARTICLE

    Comprehensive molecular analysis to predict the efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer

    SUNG HEE LIM1,#, HEE JIN CHO1,2,3,#, KYOUNG-MEE KIM4, HO YEONG LIM1, WON KI KANG1, JEEYUN LEE1, YOUNG SUK PARK1, HEE CHEOL KIM5,*, SEUNG TAE KIM1,*

    Oncology Research, Vol.31, No.6, pp. 855-866, 2023, DOI:10.32604/or.2023.030374

    Abstract Background: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported. Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues. Results: Genomic and molecular characterization was successfully conducted in 103 patients. Six of 103 CRC samples were hypermutated, and none of the non-hypermutant tumors were microsatellite unstable. Among those 103 patients, 89… More >

  • Open Access

    RETRACTION

    Retraction: Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine: A Clinical Trial

    Xingbang Li1,#, Xuan Zheng2,#, Bowen Jin1, Yunyan Li1, Yongyu Shao1, Xiaoxian Deng1, Dingyang Li1, Shanshan Li1, Hongmei Zhou1, Jie Zhang3, Xianya Zhang4, Qunshan Shen1, Gangcheng Zhang2,*

    Congenital Heart Disease, Vol.18, No.4, pp. 489-489, 2023, DOI:10.32604/chd.2023.031413

    Abstract This article has no abstract. More >

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