GUODONG XIAO1,#, FENG CHENG1,#, JING YUAN1, WEIPING LU1, PEILI WANG2, HUIJIE FAN1,*
Oncology Research, Vol.30, No.1, pp. 35-51, 2022, DOI:10.32604/or.2022.026616
Abstract Distant metastasis is a major cause of increased mortality in breast cancer patients, but the mechanisms underlying breast cancer metastasis remain poorly understood. In this study, we aimed to identify a metastasis-related gene (MRG) signature for predicting progression in breast cancer. By screening using three regression analysis methods, a 9-gene signature (NOTCH1, PTP4A3, MMP13, MACC1, EZR, NEDD9, PIK3CA, F2RL1 and CCR7) was constructed based on an MRG set in the BRCA cohort from TCGA. This signature exhibited strong robustness, and its generalizability was verified in the Metabric and GEO cohorts. Of the nine MRGs, EZR is an oncogenic gene with… More >
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