Fatemeh Rahbar1, Avid Farhang Fagheh2, Ayda Khosravi2, Siavash Shariatzadeh2,3,*, Reza Akhavan-Sigari4
Molecular & Cellular Biomechanics, Vol.18, No.4, pp. 187-199, 2021, DOI:10.32604/mcb.2021.017750
Abstract The protein ERp57 is a stress-responsive protein, mainly exists in the endoplasmic reticulum (ER), and a small amount in the cell membrane, cytoplasm, nucleus and mitochondria, which is involved in the signal transduction from the cell surface, the regulation process that occurs in the nucleus, and the formation of polymer protein complexes involved in DNA repair. Various degrees of ERp57 dysregulation has been observed in many types of non-communicable diseases especially in cancers. Previous studies showed that the expression of ERp57 could play a key role in occurrence and development of cancers such as breast cancer, gastric cancer, ovarian cancer,… More >
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