Jinfeng Qu*, Lei Zhang†, Lanyu Li*, Yujie Su*
Oncology Research, Vol.27, No.1, pp. 81-88, 2019, DOI:10.3727/096504018X15202988139874
Abstract This study investigated the tumor-suppressive role of miR-148b in regulating endoplasmic reticulum metalloprotease 1 (ERMP1) expression and the oxidative stress response in endometrial cancer cells. Human endometrial cancer RL95-2 cells were used and transfected with miR-148b mimic, miR-148b inhibitor, or their
scrambled negative control. Thereafter, the transfection efficiency was determined by RT-qPCR, and cell proliferation was assessed by MTT assay. The dual-luciferase reporter assay, Western blot, and RT-qPCR were
conducted to determine the target gene of miR-148b. ERMP1 is a putative target of miR-148b, and thereby the
overexpression and downregulation of ERMP1 on the proliferation… More >
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