Shiyang Zhang^1,#, Jingchen Li^1,#, Qianxu Jin², Siyu Zhu¹, Hongshan Yan², Yizheng Wang³, Zihan Song¹, Liqiang Liu^1,*

Oncology Research, Vol.33, No.10, pp. 2961-2979, 2025, DOI:10.32604/or.2025.064300 - 26 September 2025

Abstract Background: Glioma is the most common tumor of the central nervous system with a poor prognosis. This study aims to explore the role of calcium/calmodulin-dependent protein kinase IIβ (CAMK2B) in regulating the malignant progression of glioma cells, as well as the molecular mechanisms underlying these malignant behaviors. Methods: The correlation between CAMK2B expression in gliomas and patient prognosis was analyzed using immunohistochemistry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and western blot. Furthermore, the study explored the role of CAMK2B in glioma cell proliferation, invasion, and migration using cell counting kit-8 (CCK-8), 5-Ethynyl-2^′-deoxyuridine (EdU), wound healing,… More >

Lingjuan Linghu^1,#, Hongying Zhou^2,#, Gang Zheng¹, Tao Yi^1,*

Oncology Research, Vol.33, No.9, pp. 2421-2434, 2025, DOI:10.32604/or.2025.063724 - 28 August 2025

Abstract Objectives: Ovarian cancer, a leading cause of gynecological malignancy-related mortality, is characterized by limited therapeutic options and a poor prognosis. Although pyrimethamine has emerged as a promising candidate demonstrating efficacy in treating various tumors, the precise mechanisms of its antitumor effects remain obscure. This study was specifically designed to investigate the mode of action underlying the antitumor effects of pyrimethamine in preclinical settings. Methods: The effects of pyrimethamine on cellular proliferation were meticulously assessed using both the cell counting kit 8 (CCK-8) assay and the colony formation assay, with the effects further confirmed in a… More >

CHENG CHENG^1,2,3, CHAO SHI^1,2, SHANG WU^1,2, WEIXING WU³, JINGPING LI^1,2, SINUO GAO^1,2, MENG HAN³, YIMIN WANG³, XIANGMEI ZHANG^2,4,*, YUNJIANG LIU^1,2,*

Oncology Research, Vol.33, No.7, pp. 1633-1648, 2025, DOI:10.32604/or.2025.061637 - 26 June 2025

Abstract Objectives: While programmed cell death 1 (PD-1) inhibitors have improved cancer treatment, the function and mechanisms of programmed cell death ligand 1 (PD-L1), particularly when expressed by cancer cells, remain unclear. This study aims to explore the role of PD-L1 within breast cancer cells and identify key targets for future immunotherapy. Methods: RNA-seq was performed on breast cancer cells with silenced PD-L1 to screen for differentially expressed genes, followed by bioinformatics analysis. Clinical specimens from breast cancer patients undergoing primary surgery without preoperative treatment were collected, along with in vitro analysis to validate the potential mechanism. Results:… More >

LAN ZHOU^1,#, QI ZHANG^2,#, BO TIAN^1,*, FENG YANG^1,*

BIOCELL, Vol.48, No.7, pp. 1081-1093, 2024, DOI:10.32604/biocell.2024.049878 - 03 July 2024

Abstract Background: Glioblastoma, a notably malignant tumor within the central nervous system, is distinguished by its aggressive behavior. Silvestrol, a robust inhibitor of the RNA helicase eukaryotic initiation factor 4A (eIF4A), has shown significant potential as an anticancer compound. Yet, the impact of silvestrol on glioblastoma, especially its molecular mechanisms, has not been fully elucidated. Methods: This investigation employed a variety of in vitro assays, such as cell counting kit-8 (CCK-8), clonogenic, 5-ethynyl-2′-deoxyuridine (EDU), wound healing, and flow cytometry, to evaluate cell cycle progression, apoptosis, cell viability, and migration. Western blot analysis was also performed to study… More >

Hui Li^*1, Huicheng Chen^†1, Haibin Wang^‡, Yilong Dong^†, Min Yin^†, Liang Zhang^§, Jia Wei^*

Oncology Research, Vol.26, No.4, pp. 557-563, 2018, DOI:10.3727/096504017X15000784459799

Abstract Hepatocellular carcinoma (HCC) is a disease with poor prognosis rates and ineffective therapeutic options. Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator in tumor formation. MicroRNAs (miRNAs) play crucial roles in the development of different types of cancer. However, the underlying mechanisms of miRNAs in HCC are poorly understood. This study was aimed to investigate the role of miR-374a in HCC and its role in the regulation of expression of MIG-6. The results showed that MIG-6 overexpression significantly inhibited cell viability of HepG2 cells after 4 days posttransfection. More >

Xiaoyan Wang^*, Yongguang Xu^*, Xinlei Chen^*, Jianmin Xiao^†

Oncology Research, Vol.26, No.3, pp. 495-502, 2018, DOI:10.3727/096504017X14982578608217

Abstract This study aimed to investigate the effect of dexmedetomidine (DEX) on osteosarcoma (OS) cell line MG63 and to explore the possible relationship between DEX and miR-520-3p in OS. The results showed that DEX could upregulate miR-520-3p, which directly targeted AKT1. Additionally, miR-520-3p also inhibited MG63 cell proliferation and migration, promoted apoptosis, and suppressed protein expressions of AKT, p-AKT, p-mTOR, and p-ERK1/2. DEX can inhibit OS cell proliferation and migration and promote apoptosis by upregulating the expression level of miR-520a-3p. DEX may serve as a potential therapeutic agent in OS treatment, and miR-520a-3p may be a More >

P. Muddasani¹, H-J. Im¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 159-161, 2006, DOI:10.32604/mcb.2006.003.159

Abstract This article has no abstract. More >