Shujun Liu*1, Guigang Yan*1, Junfu Zhang†, Lianzhi Yu‡
Oncology Research, Vol.26, No.4, pp. 581-591, 2018, DOI:10.3727/096504017X14953948675403
Abstract Evidence suggests that the long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in cancer tissues, and its elevated expression is associated with hyperproliferation. However, the underlying mechanisms regarding the role of MALAT1 in retinoblastoma (RB) remain
unclear. This study aimed to explore the functional role of MALAT1 in RB by targeting miR-124. The results
showed that the expression of MALAT1 was significantly higher in the Y79 cell line than in the ARPE-19 cell
line (p<0.01). Moreover, MALAT1 silence inhibited cell viability, migration, and invasion and promoted apoptosis in Y79 cells (p< 0.05, p<0.01,… More >
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