Jia Yu, Qiyu Fang, Shuyan Meng
Oncology Research, Vol.27, No.1, pp. 47-53, 2019, DOI:10.3727/096504018X15193843443255
Abstract Non-small cell lung cancer (NSCLC) represents the leading cause of cancer-related mortality worldwide. More
and more reports have identified important roles for long noncoding RNAs (lncRNAs) in cancer development.
ENST457720 expression was upregulated in lung adenocarcinoma in a microarray-based lncRNA screen. We
determined the expression levels of ENST457720 in NSCLC tissues with quantitative real-time PCR and then
studied their clinical significance. We explored the biological significance of ENST457720 with gain- and lossof-function analyses in vitro and in vivo. In this study, ENST457720 was expressed at higher levels in NSCLC
tissues than in paired normal tissues. Higher ENST457720 expression was associated… More >
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