Hui Li*1, Huicheng Chen†1, Haibin Wang‡, Yilong Dong†, Min Yin†, Liang Zhang§, Jia Wei*
Oncology Research, Vol.26, No.4, pp. 557-563, 2018, DOI:10.3727/096504017X15000784459799
Abstract Hepatocellular carcinoma (HCC) is a disease with poor prognosis rates and ineffective therapeutic options.
Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator
in tumor formation. MicroRNAs (miRNAs) play crucial roles in the development of different types of cancer.
However, the underlying mechanisms of miRNAs in HCC are poorly understood. This study was aimed to
investigate the role of miR-374a in HCC and its role in the regulation of expression of MIG-6. The results
showed that MIG-6 overexpression significantly inhibited cell viability of HepG2 cells after 4 days posttransfection. More >
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