WEITAO ZHENG¹, DONG JIANG², SONGEN CHEN¹, MEILING WU¹, BAOQI YAN², JIAHUI ZHAI², YUNQIANG SHI², BIN XIE¹, XINGWANG XIE², KANGHONG HU^1,*, WENXUE MA^3,*

Oncology Research, Vol.32, No.12, pp. 1837-1850, 2024, DOI:10.32604/or.2024.056565 - 13 November 2024

Abstract Objectives: The Kirsten rat sarcoma virus (KRAS) G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions. This study aims to explore innovative approaches in T cell receptor (TCR) engineering and characterization to target the KRAS G12D_7-16 mutation, providing potential strategies for overcoming this therapeutic challenge. Methods: In this innovative study, we engineered and characterized two T cell receptors (TCRs), KDA11-01 and KDA11-02 with high affinity for the KRAS G12D_7-16 mutation. These TCRs were isolated from tumor-infiltrating lymphocytes (TILs) derived from tumor tissues of patients More >

Binbin Hao¹, Zhenming Liu^1,*, Yajun Deng^1,*, Dongliang Sun¹, Wei Zhang¹, Bo Yu¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.012194

Abstract The tubular fixed bed reactor is widely used in industrial production because of its strong applicability, high stability and easy maintenance. The flow dead zone in the shell of the reactor will significantly affect the overall performance of the reactor. Reducing the flow dead zone in the shell is the main way to optimize the performance of tubular fixed bed reactor. At present, most of the research on the flow dead zone of the reactor is based on the simplified reactor model, the number and size of tubes are far from the industrial requirements. In… More >

Jupudi Lakshmi Rama Prasad¹, F. Mebarek-Oudina^2,*, G. Dharmaiah³, Putta Babu Rao⁴, H. Vaidya⁵

Frontiers in Heat and Mass Transfer, Vol.22, No.5, pp. 1515-1532, 2024, DOI:10.32604/fhmt.2024.057854 - 30 October 2024

Abstract There is a strong relationship between analytical and numerical heat transfers due to thermodynamically anticipated findings, making thermo-dynamical modeling an effective tool for estimating the ideal melting point of heat transfer. Under certain assumptions, the present study builds a mathematical model of melting heat transport nanofluid flow of chemical reactions and joule heating. Nanofluid flow is described by higher-order partial non-linear differential equations. Incorporating suitable similarity transformations and dimensionless parameters converts these controlling partial differential equations into the non-linear ordinary differential equations and resulting system of nonlinear equations is established. Plotted graphic visualizations in MATLAB More >

Ying Wang¹, Jie Dang¹, Cangbi Ding^2,*, Chenyi Zheng², Yi Tang²

Energy Engineering, Vol.121, No.11, pp. 3331-3353, 2024, DOI:10.32604/ee.2024.052066 - 21 October 2024

Abstract As the large-scale development of wind farms (WFs) progresses, the connection of WFs to the regional power grid is evolving from the conventional receiving power grid to the sending power grid with a high proportion of wind power (WP). Due to the randomness of WP output, higher requirements are put forward for the voltage stability of each node of the regional power grid, and various reactive power compensation devices (RPCDs) need to be rationally configured to meet the stable operation requirements of the system. This paper proposes an optimal configuration method for multi-type RPCDs in More >

Jili Cai¹, Junyi Zhou¹, Hangyu Chen¹, Liang Huang¹, Wenming Jiang¹, Jie Liu¹, Zhongwei Li¹, Chao Cai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.011946

Abstract Effectively obtaining tritium is one of the essential issues to realize commercial and controlled nuclear fusion [1]. Conventional lithium-containing ceramic tritium breeders with pebble bed configurations in fusion reactors have shown insurmountable structural drawbacks weakening tritium extraction, including inherently low packing fractions, extensive stress concentrations, and low thermal conductivity. Therefore, extensive efforts have been devoted to enhancing tritium extraction by improving the design of tritium breeders and addressing structural drawbacks [2-4]. In this study, porous block configurations were proposed to replace conventional pebble bed configurations for the ceramic tritium breeder. Utilizing fluid-solid coupled heat transfer… More >

Chongdong Lin^1,2,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011631

Abstract In many real-world scenarios, such as high-speed combustion processes and re-entry flows in aerospace vehicles, the flow conditions often involve complex interactions between multiple chemical species and energy modes, leading to thermodynamic nonequilibrium effects. Traditional computational fluid dynamics (CFD) methods struggle to accurately capture these phenomena due to their simplifying assumptions regarding equilibrium thermodynamics. To solve this issue, the Multicomponent Discrete Boltzmann Method (MDBM) is proposed as a numerical approach to simulate compressible reactive flows with thermodynamic nonequilibrium effects. Based on kinetic theory, this method can capture the complex interactions between different species and energy… More >

Yihan Liao¹, Jingfa Li^2,*, Yi Wang^1,*, Bo Yu²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.011032

Abstract Metal Hydride (MH) is a promising hydrogen storage technique owing to its safety, availability, and high volumetric storage density. MH hydrogen storage reactor is the core component of MH hydrogen storage technology. However, the thermal effect of MH hydrogen storage reactor in the process of hydrogenation/dehydrogenation is significant, which requires an efficient heat management system for the reactor. Phase change materials (PCM) can be applied to MH hydrogen storage reactor, and have the advantages of simple structure. In this paper, representative PCM thermal management methods were summarized, and the distribution structure of the existing multi-layer… More >

Aline Ferreira Knihs, Larissa Klen Aragão, Miguel Angelo Granato, Andrea Cristiane Krause Bierhalz^*, Rita de Cassia Siqueira Curto Valle

Journal of Renewable Materials, Vol.12, No.9, pp. 1557-1571, 2024, DOI:10.32604/jrm.2024.052963 - 25 September 2024

Abstract The textile industry generates large volumes of waste throughout its production process. Most of this waste is colored, therefore, discoloration is an important step toward recycling and reusing this waste. This study focused on the chemical reductive discoloration of textile waste composed of cotton dyed with reactive dye. The experimental design demonstrated the significant influence of the concentration of reducing agent and time of reaction on the degree of whiteness of the cotton fibers. The concentration of the alkaline agent was not significant in the process. The optimization of the reaction conditions lead to Berger… More > Graphic Abstract

Xiwang Guo¹, Liangbo Zhou¹, Zhiwei Zhang^1,*, Liang Qi^2,*, Jiacun Wang³, Shujin Qin⁴, Jinrui Cao⁵

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4475-4496, 2024, DOI:10.32604/cmc.2024.048123 - 12 September 2024

Abstract This work investigates a multi-product parallel disassembly line balancing problem considering multi-skilled workers. A mathematical model for the parallel disassembly line is established to achieve maximized disassembly profit and minimized workstation cycle time. Based on a product’s AND/OR graph, matrices for task-skill, worker-skill, precedence relationships, and disassembly correlations are developed. A multi-objective discrete chemical reaction optimization algorithm is designed. To enhance solution diversity, improvements are made to four reactions: decomposition, synthesis, intermolecular ineffective collision, and wall invalid collision reaction, completing the evolution of molecular individuals. The established model and improved algorithm are applied to ball More >

Mahzad Ahmed¹, Raja Mussadaq Yousaf², Ali Hassan^3,4,*, B. Shankar Goud⁵

Frontiers in Heat and Mass Transfer, Vol.22, No.4, pp. 1261-1276, 2024, DOI:10.32604/fhmt.2024.048091 - 30 August 2024

Abstract In the current work, inclined magnetic field, thermal radiation, and the Cattaneo-Christov heat flux are taken into account as we analyze the impact of chemical reaction on magneto-hydrodynamic Casson nanofluid flow on a stretching sheet. Modified Buongiorno’s nanofluid model has been used to model the flow governing equations. The stretching surface is embedded in a porous medium. By using similarity transformations, the nonlinear partial differential equations are transformed into a set of dimensionless ordinary differential equations. The numerical solution of transformed dimensionless equations is achieved by applying the shooting procedure together with Rung-Kutta 4th-order method… More >