Weijian Song^1,, Xi Li^1,, Peng Chen^1,*, Juan Chen¹, Jianhua Ren², Yunni Xia^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3001-3016, 2024, DOI:10.32604/cmes.2024.048563

Abstract With the rapid development of Internet of Things (IoT) technology, IoT systems have been widely applied in healthcare, transportation, home, and other fields. However, with the continuous expansion of the scale and increasing complexity of IoT systems, the stability and security issues of IoT systems have become increasingly prominent. Thus, it is crucial to detect anomalies in the collected IoT time series from various sensors. Recently, deep learning models have been leveraged for IoT anomaly detection. However, owing to the challenges associated with data labeling, most IoT anomaly detection methods resort to unsupervised learning techniques.… More >

YAN-NAN LI^1,#, YUN-HONG XIU^2,#, YAN-JUN TANG³, JING-LONG CAO¹, WEN-SHUANG HOU¹, AN-QI WANG¹, TIAN-ZHU LI^4,*, CHENG-HAO JIN^1,3,5,*

BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515

Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

Yuanqing He^*, Xinyue Yu, Yu Xia, Yanhua Cao

International Journal of Mental Health Promotion, Vol.26, No.6, pp. 463-474, 2024, DOI:10.32604/ijmhp.2024.051909

Abstract Background: Teacher burnout is a serious issue in the field of education, particularly in early childhood education, where teachers face high levels of work stress and emotional labor, leading to emotional exhaustion and job burnout. However, past research has not sufficiently explored the mechanisms of social skills, empathy, and mindfulness in mitigating teacher burnout. Therefore, this study aims to investigate the relationship between preschool teachers’ social skills, empathy, and mindfulness with job burnout, in order to provide theoretical basis and practical guidance for reducing teacher burnout. Methods: This research utilized a convenience sampling approach to… More >

Ivan Sboev^1,*, Tatyana Lyubimova^2,3, Konstantin Rybkin³, Michael Kuchinskiy^2,3

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1425-1439, 2024, DOI:10.32604/fdmp.2024.051341

Abstract The intensification of physicochemical processes in the sonochemical reactor chamber is widely used in problems of synthesis, extraction and separation. One of the most important mechanisms at play in such processes is the acoustic cavitation due to the non-uniform distribution of acoustic pressure in the chamber. Cavitation has a strong impact on the surface degradation mechanisms. In this work, a numerical calculation of the acoustic pressure distribution inside the reactor chamber was performed using COMSOL Multiphysics. The numerical results have revealed the dependence of the structure of the acoustic pressure field on the boundary conditions More > Graphic Abstract

Nadezhda Zubova^*, Andrey Ivantsov

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1407-1424, 2024, DOI:10.32604/fdmp.2024.051130

Abstract The study deals with the numerical modeling of leachate distribution in the porous medium located under a municipal solid waste disposal landfill (MSWLF). The considered three-layer system is based on geological data obtained from field measurements. For simplicity, the problem is investigated by assuming a two-component approach. Nevertheless, the heat produced by landfills due to biological and chemical processes and the thermal diffusion mechanism contributing to pollution transport are taken into account. The numerical modeling of the propagation of leachate in the considered layered porous medium is implemented for parameters corresponding to natural soil and More >

Mengdong An¹, Weiyuan Zhong¹, Wei Xu², Xiuli Wang^1,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1331-1349, 2024, DOI:10.32604/fdmp.2023.046604

Abstract The reactor coolant pump (RCP) rotor seizure accident is defined as a short-time seizure of the RCP rotor. This event typically leads to an abrupt flow decrease in the corresponding loop and an ensuing reactor and turbine trip. The significant reduction of core coolant flow while the reactor is being operated at full load can have very negative consequences. This potentially dangerous event is typically characterized by a complex transient behavior in terms of flow conditions and energy transformation, which need to be analyzed and understood. This study constructed transient flow and rotational speed mathematical More > Graphic Abstract

CARLOS ALBERTO-SILVA^*, BRENDA RUFINO DA SILVA

BIOCELL, Vol.48, No.6, pp. 897-904, 2024, DOI:10.32604/biocell.2024.050443

Abstract Venom snake-derived peptides have multiple biochemical, pharmacological, and toxicological profiles, allowing for the discovery of new medicinal products and therapeutic applications. This review specifically examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake venom. It also includes a brief evaluation of short peptides that are being considered as potential therapeutic agents. Proline-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes, specifically Bothrops atrox, Bothrops jararaca, and Bothrops moojeni, have been shown to have pro-survival properties, the ability to reduce oxidative stress, and the ability to promote cell viability More >

LITING WEN^#, XIAOXIA ZENG^#, PEIXIONG CHEN, DAPENG ZHAO, YANGYANG LI, XIANHAI ZENG^*

BIOCELL, Vol.48, No.6, pp. 991-999, 2024, DOI:10.32604/biocell.2024.050219

Abstract Background: Cochlear hair cell injury is a common pathological feature of hearing loss. The basic helix-loop-helix family, member e40 (Bhlhe40), a gene belonging to the basic helix-loop-helix (bHLH) family, exhibits strong transcriptional repression activity. Methods: Oxidative damage, in House Ear Institute-Organ of Corti 1 (HEI‑OC1) cells, was caused using hydrogen peroxide (HO). The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 cells. Various assays including cell counting kit-8 (CCK-8), terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay (TUNEL), flow cytometry, immunofluorescence, and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability, apoptosis,… More > Graphic Abstract

Michael Kuchinskiy^1,2,*, Tatyana Lyubimova^1,2, Konstantin Rybkin², Anastasiia Sadovnikova², Vasiliy Galishevskiy²

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1093-1102, 2024, DOI:10.32604/fdmp.2024.050059

Abstract Ultrasonic baths and sonochemical reactors are widely used in industrial applications dealing with surface cleaning and chemical synthesis. The processes of erosion, cleaning and structuring of the surface can be typically controlled by changing relevant influential parameters. In particular, in this work, we experimentally investigate the effect of NaCl concentration (0–5.5 mol/L) on the erosion of an aluminum foil under ultrasonic exposure at a frequency of 28 kHz. Special attention is paid to the determination of cavitation zones and their visualization using heat maps. It is found that at low NaCl concentration (0.3 mol/L), the More > Graphic Abstract

Makoto Akiyama^*†, Yoshihiro Sowa^*, Tomoyuki Taniguchi^*, Motoki Watanabe^*, Shingo Yogosawa^‡, Jo Kitawaki^†,Toshiyuki Sakai^*

Oncology Research, Vol.25, No.8, pp. 1245-1252, 2017, DOI:10.3727/096504017X14850164661097

Abstract Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three combined treatments (TCTs)—a novel histone deacetylase (HDAC) inhibitor OBP-801/YM753, 5-fluorouracil (5-FU), and paclitaxel (PTX)—in human ovarian cancer SKOV-3 and OVCAR-3 cells. The inhibition of cell growth was stronger with TCTs than with each single agent and with two combined treatments. The TCTs significantly induce G₂ phase arrest in both cell lines. We then analyzed the molecular mechanisms and found that the TCTs increased the More >