Liyan Dou*1,
Kaiyu Han†1,
Mochao Xiao*, Fuzhen Lv†
Oncology Research, Vol.27, No.2, pp. 261-268, 2019, DOI:10.3727/096504018X15219188894056
Abstract miR-223-5p has been demonstrated to regulate the development and progression of various cancers, such
as hepatocellular carcinoma, breast cancer, and gastric carcinoma. However, the role of miR-223-5p in nonsmall cell lung cancer (NSCLC) requires further investigation. In this study, we found that the expression
of miR-223-5p was significantly downregulated in NSCLC tissues and cell lines. Moreover, the expression
level of miR-223-5p is negatively correlated with the malignance of NSCLC. We found that overexpression
of miR-223-5p remarkably suppressed the proliferation of NSCLC cells in vitro and in vivo. miR-223-5p
overexpression also led to reduced migration and More >
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