Chao Ma, Jinfeng Han, Dong Dong, Nanya Wang
Oncology Research, Vol.26, No.5, pp. 765-773, 2018, DOI:10.3727/096504017X15021536183535
Abstract MicroRNA-152 (miR-152) expression has been reported to be downregulated in osteosarcoma (OS). However,
the role of miR-152 in OS is not well documented. In the present study, we aimed to explore the function and
underlying mechanism of miR-152 in OS. We found that miR-152 was underexpressed in OS tissues and cell
lines. Decreased miR-152 was inversely correlated with lymph node metastasis and advanced clinical stage.
Overexpression of miR-152 significantly inhibited cell proliferation, colony formation, migration, and invasion
of OS cells. Bioinformatics analyses showed that miR-152 directly targeted E2F transcription factor 3 (E2F3),
as further confirmed More >
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