Lunjian Chen*, Xiaorong Huang†, Xinxin Chen‡
Oncology Research, Vol.26, No.9, pp. 1375-1382, 2018, DOI:10.3727/096504018X15188352857437
Abstract Cholangiocarcinoma (CCA) is one of the most malignant adenocarcinomas arising from bile duct epithelial
cells. However, the molecular mechanism regulating CCA development and progression still needs to be investigated. Here we found that miR-365 was downregulated in CCA tissues compared with adjacent normal tissues. By functional experiments, we found that overexpression of miR-365 significantly inhibited CCA cell
proliferation and promoted cellular apoptosis in vitro. Furthermore, administration with miR-365 markedly
suppressed the growth of tumor tissues in vivo. Mechanistically, we identified E2F2 as the target gene of miR-
365 in CCA cells. We found that overexpression More >
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