Matthew Rubinstein^1,*, Madeline Lauren Hong¹, Rishi Kumar Nanda¹, Daniel Thomas Jones¹, Hazem Aboaid², Yin Mon Myat³, Kyaw Zin Thein⁴

Oncology Research, Vol.33, No.11, pp. 3161-3183, 2025, DOI:10.32604/or.2025.067791 - 22 October 2025

Abstract The ever-expanding development of tissue-agnostic therapies which target malignancies based on specific mutations rather than tissue origin have transformed the landscape of oncology. The purpose of this review is to explore the impact, safety, and challenges of tissue-agnostic therapies including pembrolizumab, dostarlimab, larotrectinib, entrectinib, repotrectinib, dabrafenib plus trametinib, selpercatinib, and trastuzumab deruxtecan. As the therapeutic arsenal continues to grow, it is crucial to understand how these therapies truly benefit patients and to address the barriers that stand in the way of making them more widely available. Although these therapies have shown effectiveness across multiple cancer More >

Azhar Iqbal Kashif Butt^1,*, Tariq Ismaeel^2,*, Sara Khan², Muhammad Imran³, Waheed Ahmad², Ismail Abdulrashid⁴, Muhammad Sajid Riaz⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 3463-3492, 2025, DOI:10.32604/cmes.2025.069277 - 30 September 2025

Abstract Malaria is a significant global health challenge. This devastating disease continues to affect millions, especially in tropical regions. It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes. This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria, incorporating both human and mosquito populations. We aim to identify the key factors driving the endemic spread of malaria, determine feasible solutions, and provide insights that lead to the development of effective prevention and management strategies. We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and… More >

YA-LING YEH¹, YING-JAN WANG¹, SHOEI-YN LIN-SHIAU^2,3,*

Oncology Research, Vol.33, No.7, pp. 1781-1796, 2025, DOI:10.32604/or.2025.063717 - 26 June 2025

Abstract Background: The increasing incidence of cancers and infectious diseases worldwide presents a significant public health challenge that requires immediate intervention. Our strategy to tackle this issue involves the development of pharmaceutical formulations that combine phytopolyphenols (P), targeted drugs (T), and metal ions (M), collectively referred to as PTM regimens. The diverse pharmacological properties of PTM regimens are hypothesized to effectively reduce the risk factors associated with both cancers and infectious diseases. Methods: The effects of the pharmaceutical agents on the proliferation of cultured cancer cells and pathogens were assessed after 72 h and 48 h,… More >

MICHELE MAFFEZZOLI^1,2,#, GIULIA CLAIRE GIUDICE^1,2,#,*, GIACOMO IOVANE^1,2, MARTINA MANINI^1,2, ELENA RAPACCHI¹, GIUSEPPE CARUSO¹, NICOLA SIMONI³, STEFANIA FERRETTI⁴, STEFANO PULIATTI⁴, DAVIDE CAMPOBASSO⁵, SEBASTIANO BUTI^1,2

Oncology Research, Vol.33, No.4, pp. 741-757, 2025, DOI:10.32604/or.2024.057278 - 19 March 2025

Abstract Background: immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic urothelial carcinoma (mUC), significantly improving survival outcomes. However, a subset of patients do not respond to ICIs, prompting research into potential predictive factors. Commonly prescribed medications such as corticosteroids, proton-pump inhibitors (PPIs), antibiotics (Abs), antihypertensives, and analgesics may influence ICI effectiveness. Methods: we conducted a literature search on PubMed to investigate the impact of concomitant medications on the outcomes of patients with mUC, treated with ICIs. We selected the most relevant studies and performed a narrative review. Results: corticosteroids, PPIs and Abs have been associated More >

GIULIANO BERNAL^*, GISELA AQUEA, SEBASTIÁN RAMÍREZ-RIVERA

Oncology Research, Vol.33, No.4, pp. 759-779, 2025, DOI:10.32604/or.2024.057019 - 19 March 2025

Abstract Cancer remains one of the leading causes of death in the world, with more than 9 million deaths in 2022, a number that continues to rise. This highlights the urgent need for the development of new drugs, with enhanced antitumor capabilities and fewer side effects. Metal-based drugs have been used in clinical practice since the late 1970s, beginning with the introduction of cisplatin. Later, two additional platinum-based molecules, carboplatin, and oxaliplatin, were introduced, and all three continue to be widely used in the treatment of various cancers. However, despite their significant anticancer activity, the undesirable… More > Graphic Abstract

JHILAM PRAMANIK^1,#, AKASH KUMAR², SARVESH RUSTAGI^3,#, MEHAK KATYAL⁴, SHEETAL THAKUR⁵, JUTISHNA BORA⁶, SUMIRA MALIK^6,7,*, ANCHAL TREHAN⁸, NAYAN TALUKDAR⁹, PETR SLAMA^10,*

BIOCELL, Vol.48, No.4, pp. 541-557, 2024, DOI:10.32604/biocell.2023.029031 - 09 April 2024

Abstract Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods, pharmaceutical products as well as in the environmental and medical fields. However, these secondary metabolites obtained from plants are in low amounts, and it is difficult to synthesize them at the industrial level. Despite these challenges, they may be utilized for a variety of medicinal products that are either available in the market or are being researched and tested. Secondary metabolites are complex compounds that exhibit chirality. Further, under controlled conditions with elicitors, desired secondary metabolites may be produced from More > Graphic Abstract

Leonard G. Gomella

Canadian Journal of Urology, Vol.30, No.6, pp. 11708-11709, 2023

Abstract This article has no abstract. More >

QIANG WANG^#, GUO ZHAO^#, LONGXIANG XIE^#, XUAN LI, XIXI YU, QIONGSHAN LI, BAOPING ZHENG, ZULIPINUER WUSIMAN, XIANGQIAN GUO^*

BIOCELL, Vol.47, No.2, pp. 367-371, 2023, DOI:10.32604/biocell.2023.025310 - 18 November 2022

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of the ongoing coronavirus disease 2019 (COVID-19) global pandemic. Here, by centralizing published cell-based experiments, clinical trials, and virtual drug screening data from the NCBI PubMed database, we developed a database of SARS-CoV-2 inhibitors for COVID-19, dbSCI, which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments, 81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses. dbSCI provides four major functions: (1) search the drug target or its inhibitor for SARS-CoV-2, (2) browse target/inhibitor information collected from More >

Eleni P. Asimacopoulos^*, Steven J. Staffa, Peter C. Laussen, Kirsten C. Odegard

Congenital Heart Disease, Vol.17, No.5, pp. 579-590, 2022, DOI:10.32604/chd.2022.020334 - 06 September 2022

Abstract Background: Thromboembolic events are a cause of significant morbidity and mortality in the Fontan population. We previously reported on coagulation profile changes in a cohort of patients with hypoplastic left heart syndrome (HLHS) from Stage I through Fontan completion. In this report, we examine their clinical status, anticoagulation and incidence of thromboembolic events up to 20 years post Fontan. Methods: A retrospective chart review was conducted for twenty (20) surviving patients, from 1998 through December 2020. Patients who underwent orthotopic heart transplantation (OTx) were followed until their transplant. Patients who were found in the original study… More >

Fawaz Alsolami¹, Abdullah Saad Al-Malaise Alghamdi², Asif Irshad Khan^1,*, Yoosef B. Abushark¹, Abdulmohsen Almalawi¹, Farrukh Saleem², Alka Agrawal³, Rajeev Kumar⁴, Raees Ahmad Khan³

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 2591-2618, 2022, DOI:10.32604/cmc.2022.025703 - 16 June 2022

Abstract The COVID-19 pandemic has triggered a global humanitarian disaster that has never been seen before. Medical experts, on the other hand, are undecided on the most valuable treatments of therapy because people ill with this infection exhibit a wide range of illness indications at different phases of infection. Further, this project aims to undertake an experimental investigation to determine which treatments for COVID-19 disease is the most effective and preferable. The research analysis is based on vast data gathered from professionals and research journals, making this study a comprehensive reference. To solve this challenging task,… More >