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Search Results (11)
  • Open Access

    ARTICLE

    dbSCI: A manually curated database of SARS-CoV-2 inhibitors for COVID-19

    QIANG WANG#, GUO ZHAO#, LONGXIANG XIE#, XUAN LI, XIXI YU, QIONGSHAN LI, BAOPING ZHENG, ZULIPINUER WUSIMAN, XIANGQIAN GUO*

    BIOCELL, Vol.47, No.2, pp. 367-371, 2023, DOI:10.32604/biocell.2023.025310

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of the ongoing coronavirus disease 2019 (COVID-19) global pandemic. Here, by centralizing published cell-based experiments, clinical trials, and virtual drug screening data from the NCBI PubMed database, we developed a database of SARS-CoV-2 inhibitors for COVID-19, dbSCI, which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments, 81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses. dbSCI provides four major functions: (1) search the drug target or its inhibitor for SARS-CoV-2, (2) browse target/inhibitor information collected from cell experiments, clinical trials, and… More >

  • Open Access

    ARTICLE

    A 20-Year Follow-up after the Fontan Operation in a Population with Hypoplastic Left Heart Syndrome

    Eleni P. Asimacopoulos*, Steven J. Staffa, Peter C. Laussen, Kirsten C. Odegard

    Congenital Heart Disease, Vol.17, No.5, pp. 579-590, 2022, DOI:10.32604/chd.2022.020334

    Abstract Background: Thromboembolic events are a cause of significant morbidity and mortality in the Fontan population. We previously reported on coagulation profile changes in a cohort of patients with hypoplastic left heart syndrome (HLHS) from Stage I through Fontan completion. In this report, we examine their clinical status, anticoagulation and incidence of thromboembolic events up to 20 years post Fontan. Methods: A retrospective chart review was conducted for twenty (20) surviving patients, from 1998 through December 2020. Patients who underwent orthotopic heart transplantation (OTx) were followed until their transplant. Patients who were found in the original study to have a factor… More >

  • Open Access

    ARTICLE

    Nonsteroidal Anti-inflammatory Drugs Sensitize CD44-Overexpressing Cancer Cells to Hsp90 Inhibitor Through Autophagy Activation

    Hyun-Jung Moon,1 So-Young Park,1 Su-Hoon Lee, Chi-Dug Kang, Sun-Hee Kim

    Oncology Research, Vol.27, No.7, pp. 835-847, 2019, DOI:10.3727/096504019X15517850319579

    Abstract Recently, novel therapeutic strategies have been designed with the aim of killing cancer stem-like cells (CSCs), and considerable interest has been generated in the development of specific therapies that target stemnessrelated marker of CSCs. In this study, nonsteroidal anti-inflammatory drugs (NSAIDs) significantly potentiated Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG)-mediated cytotoxicity through apoptotic and autophagic cell death induction, but COX-2-inhibitory function was not required for NSAIDinduced autophagy in CD44-overexpressing human chronic myeloid leukemia K562 (CD44highK562) cells. Importantly, we found that treatment with NSAIDs resulted in a dose-dependent increase in LC3-II level and decrease in p62 level and simultaneous reduction in multiple stemness-related markers… More >

  • Open Access

    ARTICLE

    A Unified Decision-Making Technique for Analysing Treatments in Pandemic Context

    Fawaz Alsolami1, Abdullah Saad Al-Malaise Alghamdi2, Asif Irshad Khan1,*, Yoosef B. Abushark1, Abdulmohsen Almalawi1, Farrukh Saleem2, Alka Agrawal3, Rajeev Kumar4, Raees Ahmad Khan3

    CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 2591-2618, 2022, DOI:10.32604/cmc.2022.025703

    Abstract The COVID-19 pandemic has triggered a global humanitarian disaster that has never been seen before. Medical experts, on the other hand, are undecided on the most valuable treatments of therapy because people ill with this infection exhibit a wide range of illness indications at different phases of infection. Further, this project aims to undertake an experimental investigation to determine which treatments for COVID-19 disease is the most effective and preferable. The research analysis is based on vast data gathered from professionals and research journals, making this study a comprehensive reference. To solve this challenging task, the researchers used the HF… More >

  • Open Access

    REVIEW

    Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy

    ZIQIAN WANG1,2,#, YAQI LI1,2,#, DONGYANG WANG1,2, YINGQIANG SHEN1,3,4,5,*

    BIOCELL, Vol.46, No.7, pp. 1599-1611, 2022, DOI:10.32604/biocell.2022.018530

    Abstract Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis have glutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation, Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly, many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, the study of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolic process of ferroptosis, the role… More >

  • Open Access

    ARTICLE

    From Similarities to Probabilities: Feature Engineering for Predicting Drugs’ Adverse Reactions

    Nahla H. Barakat*, Ahmed H. ElSabbagh

    Intelligent Automation & Soft Computing, Vol.32, No.2, pp. 1207-1224, 2022, DOI:10.32604/iasc.2022.022104

    Abstract Social media recently became convenient platforms for different groups with common concerns to share their experiences, including Adverse Drug Reactions (ADRs). In this paper, we propose a two stage intelligent algorithm which we call “Simi_to_Prob”, that utilizes social media forums; for ranking ADRs, and evaluating the ADRs prevalence considering different age and gender groups as its first stage. In the second stage, ADRs are predicted utilizing a different data set from the Food and Drug Administration (FDA). In particular, Natural Language Processing (NLP) is used on social media to extract ranked lists of ADRs, which are then validated using novel… More >

  • Open Access

    ARTICLE

    Repurposing of FDA-Approved drugs to predict new inhibitors against key regulatory genes in Mycobacterium tuberculosis

    XINJUN YANG1, AFTAB ALAM2, NAIYAR IQBAL3, KHALID RAZA4,*

    BIOCELL, Vol.45, No.6, pp. 1569-1583, 2021, DOI:10.32604/biocell.2021.017019

    Abstract

    Tuberculosis (TB) disease has become one of the major public health concerns globally, especially in developing countries. Numerous research studies have already been carried out for TB, but we are still struggling for a complete and quick cure for it. The progress of Mycobacterium tuberculosis (MTB) strains resistant to existing drugs makes its cure and control very complicated. Therefore, it is the need of the hour to search for newer and effective drugs that can inhibit an increasing number of putative drug targets. We applied the drug repurposing concept to identify promising FDA-approved drugs against five key-regulatory genes (FurB, IdeR,… More >

  • Open Access

    REVIEW

    Biodegradable Materials as Nanocarriers for Drugs and Nutrients

    Xingran Kou1,2, Qixuan Zhao2, Wenwen Xu2, Zuobing Xiao2, Yunwei Niu2, Kai Wang3,*

    Journal of Renewable Materials, Vol.9, No.7, pp. 1189-1211, 2021, DOI:10.32604/jrm.2021.015268

    Abstract Several important drugs and nutritional supplements are limited by their lack of bioavailability. Nanomaterials display unique beneficial properties that might help improve the bioavailability of drugs and nutritional supplements. Unfortunately, nanomaterials produced from synthetic polymers and metals may have similar difficulties with bioavailability and toxicity. Naturally occurring biopolymers are biodegradable and non-toxic and are adaptable to the synthesis of nanoparticles. Drugs and other substances can be encapsulated or embedded in such particles with an increase in bioavailability. The search for biodegradable nanomaterials is an active research field. This review summarizes the research on nanocrystalline cellulose, starch, lignin, and other biological… More >

  • Open Access

    ARTICLE

    Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis

    Aknur Turgumbayeva1,2, Gulbaram Ustenova1, Ubaidilla Datkhayev1, Khairolla Rahimov3, Silvijus Abramavicius4,5, Agile Tunaityte4,*, Kairat Zhakipbekov1,6, Kaldanay Kozhanova1, Saken Tulemissov7, OzikhanUstenova8, Gulmira Datkayeva9, Edgaras Stankevicius1,10

    Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 137-146, 2020, DOI:10.32604/phyton.2020.07665

    Abstract In this research we present that Carthamus Tinctorius L. (gen. Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in Cryptococcal infections, malaria and Leishmaniasis, as treatment options are becoming scarce due to drug resistance development. Phytochemistry and pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. tinctorius L. were analyzed. The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. 8 known and 3 unknown compounds were detected in the extract (Fig. 1). Then the Safflower ointment was… More >

  • Open Access

    ARTICLE

    Germinating seeds of the mung bean, Vigna radiata (Fabaceae), as a model for the preliminary evaluation of cytotoxic effects of drugs

    VIJAY L. KUMAR*, ABHISHEK SINGHAL

    BIOCELL, Vol.33, No.1, pp. 19-24, 2009, DOI:10.32604/biocell.2009.33.019

    Abstract Cytotoxic properties of plant extracts and drugs being developed for cancer treatment are usually evaluated by a variety of in vivo and in vitro tests carried out in animal or plant based models. In the present study we have evaluated the possibility of using the germinating mung beans (Vigna radiata), for rapid and inexpensive screening of drugs exhibiting cytotoxic properties. Mung beans were allowed to germinate either in tap water or in different drug solutions, and parameters like percent germination, increase in radicle length, change in seedling weight and mitotic index of apical root meristems were determined at two time… More >

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