Osama M. AHMED1,*, Sanaa R. GALALY2, Mai RASLAN3, Mennah-Allah M. A. MOSTAFA1,*
BIOCELL, Vol.44, No.1, pp. 41-53, 2020, DOI:10.32604/biocell.2020.08157
- 01 March 2020
Abstract This study aimed to assess the preventive effects of thyme oil and thymol on doxorubicin (DOX)-induced
renotoxicity, cardiotoxicity, and oxidative stress in Wistar rats. Thyme oil was subjected to GC-MS analysis, which
indicated that thymol was the major constituent representing 33.896%. Rats intraperitoneally injected with DOX at
a dose of 2 mg/kg b.w./one per week for 7 weeks were co-treated with thyme oil and its major constituent, thymol, at
doses 250 and 100 mg/kg b.w./every other day, respectively, by oral gavage for the same period. Thyme oil and thymol
markedly ameliorated the raised levels of… More >
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