Dong Hwan Ho^1,*, Minhyung Lee^2,3, Daleum Nam¹, Hyejung Kim¹, Janghwan Kim^2,3, Mi Kyoung Seo^4,5, Sung Woo Park^4,5, Ilhong Son^1,6,*

BIOCELL, Vol.49, No.7, pp. 1225-1244, 2025, DOI:10.32604/biocell.2025.065486 - 25 July 2025

Abstract Background: Parkinson’s disease (PD) is a common neurodegenerative disease, characterized by symptoms like tremors, muscle rigidity, and slow movement. The main cause of these symptoms is the loss of dopamine-producing neurons in a brain area called the substantia nigra. Various genetic and environmental factors contribute to this neuronal loss. Once symptoms of PD begin, they worsen with age, which also impacts several critical cellular processes. Leucine-rich repeat kinase 2 (LRRK2) is a gene associated with PD. Certain mutations in LRRK2, such as G2019S, increase its activity, disrupting cellular mechanisms necessary for healthy neuron function, including… More >

Yiqin He^1,2, Chenhan Hu^1,2, Xiangshu Meng^1,2, Rundong Ma^1,2, Kexin Duan^1,2, Yu Guo^2,3, Changqing Liu^1,2, Caiyun Ma^1,2, Gaofeng Liu^1,2,*, Chunjing Wang^1,2,*

BIOCELL, Vol.49, No.6, pp. 1037-1055, 2025, DOI:10.32604/biocell.2025.064633 - 24 June 2025

Abstract Background: Mesenchymal stem cells (MSCs) have shown great potential in treating neurodegenerative diseases, including Parkinson’s disease (PD), due to their ability to differentiate into neurons and secrete neurotrophic factors. Genetic modification of MSCs for PD treatment has become a research focus. Methods: In this study, rat pulmonary mesenchymal stem cells (PMSCs) were transduced with lentiviral vectors carrying Lmx1a/NeuroD1 to establish genetically engineered PMSCs (LN-PMSCs) and induce their differentiation into dopaminergic neurons. The LN-PMSCs were then transplanted into the right medial forebrain bundle region of PD model rats prepared using the 6-Hydroxydopamine (6-OHDA) method. Four weeks… More >

Jinliang Luo, Dongliang Li, Yang Li, Miaojiao Wang, Xiaomin Kang, Zhitao Hu^*

Journal of Polymer Materials, Vol.42, No.1, pp. 125-140, 2025, DOI:10.32604/jpm.2024.059636 - 27 March 2025

Abstract With the rapid development of flexible wearable electronic products, their application fields and demands are increasing, posing new challenges to flexible conductive materials. This paper selected flexible polydimethylsiloxane (PDMS) as the substrate. In order to enhance the adhesion between the substrate and the metal coating, dopamine and silanization were used to co-modify its surface. A conductive layer of metallic copper is deposited on its surface using an inexpensive, easy-to-use electroless plating technique. By optimizing the process conditions, it is found that a uniform copper layer of about 0.6 μm can be formed on the surface More >

Y. L. Hou^*, L. Z Bai

Chalcogenide Letters, Vol.21, No.10, pp. 785-796, 2024, DOI:10.15251/CL.2024.2110.785

Abstract This study investigated the development of a novel composite modified asphalt incorporating PDA-MoS₂ into styrene-butadiene-styrene (SBS) modified asphalt. The successful synthesis of PDA-MoS₂ was confirmed through various characterization techniques. The incorporation of PDA-MoS₂ into SBS modified asphalt resulted in significant improvements in performance properties. With a PDA-MoS₂ content of 0.7 wt%, the modified asphalt showed a notable 15.1% rise in softening point and a 24% drop in penetration in comparison to the control SBS modified asphalt. Dynamic Shear Rheometer tests revealed a 2.4-fold increase in the rutting factor at 60°C. Multiple Stress Creep Recovery tests demonstrated enhanced… More >

MOHAMMAD-SADEGH LOTFI, FATEMEH B. RASSOULI^*

BIOCELL, Vol.48, No.10, pp. 1419-1428, 2024, DOI:10.32604/biocell.2024.053597 - 02 October 2024

Abstract Parkinson’s disease (PD) is one of the fastest-growing neurodegenerative disorders worldwide. So far, PD treatments only offer little clinical relief and cannot reverse or stop the disease progression. Stem cell (SC) therapy is a rapidly evolving technology that holds significant promise for enhancing current therapeutic approaches. Adipose-derived mesenchymal SCs (AD-MSCs) have many features such as easy harvest with minimal invasive techniques, high plasticity, non-immunogenicity, and no ethical issues, which have made them suitable choices for clinical applications in regenerative research. AD-MSCs are ideal tools to treat PD, as they have the potential to differentiate into… More >

VIRAAJ VISHNU PRASAD, JENNIFER SALLY SAMSON, VENKATACHALAM DEEPA PARVATHI^*

BIOCELL, Vol.48, No.5, pp. 693-706, 2024, DOI:10.32604/biocell.2024.048776 - 06 May 2024

Abstract Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual. In addition to aiding the regulation of aerobic and anaerobic metabolism, exercise can stimulate the synthesis of exerkine hormones in the circulatory system. Among several exerkines that have been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered the most promising candidate, especially in the management of neurodegenerative diseases. Owing to the ability of physical activity to enhance BDNF synthesis, several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at More > Graphic Abstract

Lianyuan Ji¹, Mingchen Shi¹, Zengkai Feng², Hui Yang^1,*

Journal of Renewable Materials, Vol.12, No.2, pp. 259-274, 2024, DOI:10.32604/jrm.2023.030599 - 11 March 2024

Abstract

Cobalt sulphides attract much attention as anode materials for Li-ion batteries (LIBs). However, its poor conductivity, low initial column efficiency and large volume changes during cycling have hindered its further development. Herein, novel interlaced CoS nanosheets were firstly prepared on Carbon Fiber Cloth (CFC) by two hydrothermal reactions followed with carbon coating via carbonizing dopamine (CoS NS@C/CFC). As a freestanding anode, the nanosheet structure of CoS not only accommodates the volume variation, but also provides a large interface area to proceed the charge transfer reaction. In addition, CFC works as both a three-dimensional skeleton and an

… More >

JUAN C. STOCKERT^1,2,*, SILVINA A. ROMERO¹, MARCELO N. FELIX-POZZI³, ALFONSO BLÁZQUEZ-CASTRO⁴

BIOCELL, Vol.47, No.4, pp. 919-928, 2023, DOI:10.32604/biocell.2023.026631 - 08 March 2023

Abstract

The ¹⁰boron neutron-capture therapy (BNCT) is an emerging antitumoral method that shows increasing biomedical interest. BNCT is based on the selective accumulation of the ¹⁰boron isotope within the tumor, which is then irradiated with low-energy thermal neutrons, generating nuclear fission that produces ⁷lithium, ⁴helium, and γ rays. Simple catechol-borate esters have been rather overlooked as precursors of melanin biosynthesis, and therefore, a proof-of-concept approach for using dopamine-borate (DABO) as a suitable boron-containing candidate for potential BNCT is presented here. DABO can spontaneously oxidize and autopolymerize in vitro, giving a soluble, eumelanin-like brown-black poly-DABO product. Melanotic melanoma cell cultures treated

… More >

Xue Huang^1,*, Zeyu Chen¹, Ruizhao Yang¹, Guangzhu Feng²

Journal of Renewable Materials, Vol.11, No.5, pp. 2301-2319, 2023, DOI:10.32604/jrm.2023.025888 - 13 February 2023

Abstract 1,3-Dioleoyl-2-palmitoylglycerol (OPO) has been a hotspot of functional oils research in recent years, but due to the high cost of sn-1,3 specific lipase in enzymatic synthesis and the lack of biocatalyst stability, large-scale industrial application is difficult. In this study, the prepared magnetic ZnFe₂O₄ was functionalized with dopamine to obtain ZnFe₂O₄@PDA, and the nano-biocatalyst ZnFe₂O₄@PDA@RML was prepared by immobilizing sn-1,3 specific lipase of Rhizomucor miehei lipase (RML) via a cross-linking method. The existence of RML on ZnFe₂O₄@PDA was confirmed by XRD, FTIR, SEM, and TEM. This strategy proved to be simple and effective because the lipase immobilized on… More > Graphic Abstract

MANOOCHEHR MESSRIPOUR¹, AZADEH MESRIPOUR²

BIOCELL, Vol.37, No.2, pp. 17-21, 2013, DOI:10.32604/biocell.2013.37.017

Abstract Tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosynthesis of dopamine and serotonin, respectively. Since both enzymes are active in striatum, and affected by age, this study was undertaken to investigate interaction between dopamine and serotonin synthesis in brain striatal synaptosomes of aging rat. Male Wistar rats (3 and 30 month old) were killed by decapitation and brain striatal synaptosomes were prepared by discontinuous Ficoll/sucrose gradient technique. Synaptosomes were incubated in the presence of added pargiline (monoamineoxidase inhibitor), dopamine or serotonin synthesized during 25 min was measured by HPLC, employing electrochemical… More >