SINEM GÖKÇE KÜTÜK1, MUSTAFA NAZIROĞLU2,3,*
BIOCELL, Vol.45, No.1, pp. 177-188, 2021, DOI:10.32604/biocell.2021.013531
Abstract A protective action of melatonin (MELAT) on docetaxel (DCT)-induced inflammation, apoptosis, and reactive free
oxygen radical (fROS) generation values via blocking of TRPM2 calcium-permeable channel was investigated in different cells
except for laryngo-tracheal epithelial (LT-Epi) cells. Hence, the protective action of MELAT on DCT-induced oxidative toxicity
and inflammation in LT-Epi tissue and cells of mice were investigated in the current study. MELAT treatment ameliorated DCTinduced mitochondrial ROS in the LT-Epi cells by reducing the generation of fROS (cytosolic and mitochondrial), lipid
peroxidation, and depolarization of the mitochondrial membrane, while increasing reduced glutathione (GSH), GSH
peroxidase,… More >
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