Widad Elbakri¹, Maheyzah Md. Siraj^1,*, Bander Ali Saleh Al-rimy¹, Sultan Noman Qasem², Tawfik Al-Hadhrami³

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 3725-3756, 2024, DOI:10.32604/cmc.2024.048105

Abstract Cloud computing environments, characterized by dynamic scaling, distributed architectures, and complex workloads, are increasingly targeted by malicious actors. These threats encompass unauthorized access, data breaches, denial-of-service attacks, and evolving malware variants. Traditional security solutions often struggle with the dynamic nature of cloud environments, highlighting the need for robust Adaptive Cloud Intrusion Detection Systems (CIDS). Existing adaptive CIDS solutions, while offering improved detection capabilities, often face limitations such as reliance on approximations for change point detection, hindering their precision in identifying anomalies. This can lead to missed attacks or an abundance of false alarms, impacting overall… More >

Cheng-Jen Ma^*†‡, Ching-Wen Huang^*‡§, Yung-Sung Yeh^*†¶, Hsiang-Lin Tsai^*§#**, Huang-Ming Hu^††‡‡, I-Chen Wu^††‡‡, Tian-Lu Cheng^§§¶¶, Jaw-Yuan Wang^{*†‡§**¶¶}

Oncology Research, Vol.25, No.5, pp. 673-679, 2017, DOI:10.3727/97818823455816X14786040691928

Abstract We analyzed the results of previously treated patients with metastatic colorectal cancer (mCRC) who received regorafenib plus FOLFIRI with the irinotecan dose escalation on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping. Thirteen patients with previously treated mCRC were subjected to UGT1A1 genotyping between October 2013 and June 2015 and were administered regorafenib plus FOLFIRI with irinotecan dose escalation. Patients with UGT1A1*1/*1 and *1/*28 genotypes were administered 180 mg/m² of irinotecan, whereas those with the UGT1A1*28/*28 genotype were administered 120 mg/m2 of irinotecan. For all patients, the irinotecan dose was increased by 30 mg/m2 every… More >

Anne Riemann^*, Antje Güttler^†, Verena Haupt^*, Henri Wichmann^†, Sarah Reime^*, Matthias Bache^†, Dirk Vordermark^†, Oliver Thews^*

Oncology Research, Vol.26, No.2, pp. 191-200, 2018, DOI:10.3727/096504017X14965111926391

Abstract Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such as augmenting metastatic potential. Therefore, the aim of this study was to analyze the complex interdependency between CA IX and the tumor microenvironment in prostate tumor cells with regard to potential therapeutic implications. CA IX was upregulated by hypoxia as well as acidosis in prostate cancer cells. This induction… More >

KIMBERLY FENECH¹, ISAAC MICALLEF^1,2, BYRON BARON^1,*

Oncology Research, Vol.32, No.6, pp. 1047-1061, 2024, DOI:10.32604/or.2024.049173

Abstract Background: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. In many cases, the poor prognosis of advanced CRC is associated with resistance to treatment with chemotherapeutic drugs such as 5-Fluorouracil (5-FU). The epithelial-to-mesenchymal transition (EMT) and dysregulation in protein methylation are two mechanisms associated with chemoresistance in many cancers. This study looked into the effect of 5-FU dose escalation on EMT and protein methylation in CRC. Materials and Methods: HCT-116, Caco-2, and DLD-1 CRC cell lines were exposed to dose escalation treatment of 5-FU. The motility and invasive potentials of the cells before… More > Graphic Abstract

Xindi Huang¹, Liwei Liang¹, Sakirin Tam², Hao Liang³, Xiong Cai⁴, Changsong Ding^1,5,*

Computer Systems Science and Engineering, Vol.48, No.3, pp. 691-704, 2024, DOI:10.32604/csse.2022.029970

Abstract Chinese Medicine (CM) has been widely used as an important avenue for disease prevention and treatment in China especially in the form of CM prescriptions combining sets of herbs to address patients’ symptoms and syndromes. However, the selection and compatibility of herbs are complex and abstract due to intrinsic relationships between herbal properties and their overall functions. Network analysis is applied to demonstrate the complex relationships between individual herbal efficacy and the overall function of CM prescriptions. To illustrate their connections and correlations, prescription function (PF), prescription herb (PH), and herbal efficacy (HE) intra-networks are… More >

Do Nang Toan^1,*, Lam Thanh Hien², Ha Manh Toan¹, Nguyen Trong Vinh², Pham Trung Hieu¹

Intelligent Automation & Soft Computing, Vol.39, No.2, pp. 319-335, 2024, DOI:10.32604/iasc.2024.046925

Abstract Cancer is one of the most dangerous diseases with high mortality. One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and technicians. In our study, we focused on the 3D dose prediction problem in radiotherapy by applying the deep-learning approach to computed tomography (CT) images of cancer patients. Medical image data has more complex characteristics than normal image data, and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the… More >

Anindita Das¹, Kanu Murmu², Biplab Mitra³, Pintoo Bandopadhyay², Ritesh Kundu⁴, Moupiya Roy⁵, Saleh Alfarraj⁶, Mohammad Javed Ansari⁷, Marian Brestic⁸, Akbar Hossain^9,*

Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 763-776, 2024, DOI:10.32604/phyton.2024.049473

Abstract Nutrient management plays a crucial role in the yield and quality of sweet corn. A field experiment was conducted in consecutive two kharif seasons in 2018 and 2019 to investigate the effect of various organic sources of nutrients in combination with inorganic sources on the yield and quality of sweet corn under new alluvial soils of West Bengal, India. Treatments were: T: Control (without fertilizers); T: 100% recommended dose (RDF) of chemical fertilizers (CF) (RDF CF); T: 100% recommended dose of N (RDN) through vermicompost (VC) (RDN VC); T: 50 RDN through CF + 50%… More >

Thanh-Lam Nguyen¹, Hao Kao¹, Thanh-Tuan Nguyen², Mong-Fong Horng^1,*, Chin-Shiuh Shieh^1,*

CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 2181-2205, 2024, DOI:10.32604/cmc.2024.047387

Abstract Since its inception, the Internet has been rapidly evolving. With the advancement of science and technology and the explosive growth of the population, the demand for the Internet has been on the rise. Many applications in education, healthcare, entertainment, science, and more are being increasingly deployed based on the internet. Concurrently, malicious threats on the internet are on the rise as well. Distributed Denial of Service (DDoS) attacks are among the most common and dangerous threats on the internet today. The scale and complexity of DDoS attacks are constantly growing. Intrusion Detection Systems (IDS) have… More >

Azar Abid Salih^1,*, Maiwan Bahjat Abdulrazaq²

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1275-1295, 2024, DOI:10.32604/cmc.2023.046101

Abstract Cyberspace is extremely dynamic, with new attacks arising daily. Protecting cybersecurity controls is vital for network security. Deep Learning (DL) models find widespread use across various fields, with cybersecurity being one of the most crucial due to their rapid cyberattack detection capabilities on networks and hosts. The capabilities of DL in feature learning and analyzing extensive data volumes lead to the recognition of network traffic patterns. This study presents novel lightweight DL models, known as Cybernet models, for the detection and recognition of various cyber Distributed Denial of Service (DDoS) attacks. These models were constructed… More >

Xiulai Li^1,2,3,4, Jieren Cheng^1,3,*, Chengchun Ruan^1,3, Bin Zhang^1,3, Xiangyan Tang^1,3, Mengzhe Sun⁵

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3265-3288, 2023, DOI:10.32604/cmc.2023.045588

Abstract With the rising adoption of blockchain technology due to its decentralized, secure, and transparent features, ensuring its resilience against network threats, especially Distributed Denial of Service (DDoS) attacks, is crucial. This research addresses the vulnerability of blockchain systems to DDoS assaults, which undermine their core decentralized characteristics, posing threats to their security and reliability. We have devised a novel adaptive integration technique for the detection and identification of varied DDoS attacks. To ensure the robustness and validity of our approach, a dataset amalgamating multiple DDoS attacks was derived from the CIC-DDoS2019 dataset. Using this, our… More >