Domenico Crea¹, Arben Dedja¹, Matteo Ponzoni^1,2, Stefania Rizzo³, Alberto Cipriani⁴, Riccardo Bariani⁴, Kalliopi Pilichou³, Maria Bueno Marinas³, Danila Azzolina⁵, Massimo A. Padalino^1,6,*

Congenital Heart Disease, Vol.19, No.5, pp. 473-487, 2024, DOI:10.32604/chd.2025.057014 - 31 December 2024

Abstract Background: Since 2015, the pulmonary artery banding (PAB), following the Giessen protocol, has treated end-stage heart failure in selected infants with preserved right ventricular function, acting as a bridge to transplant or recovery, as a result of ventricular-ventricular interaction. Objectives: To elucidate whether PAB is a feasible and reproducible procedure in a rodent model of pharmacologically induced dilated cardiomyopathy (DCM) and to evaluate PAB-induced ventricular rehabilitation. Methods: We used 49 Sprague-Dawley rats divided into four groups: a sham surgery control group, a healthy animal group undergoing PAB, a doxorubicin (DOX)- treated control group, and a DOX… More >

CONGCHEN BAI¹, QIHANG KONG², HAO TANG², SHUWEN ZHANG², JUNTENG ZHOU^3,*, XIAOJING LIU^2,4,*

BIOCELL, Vol.47, No.11, pp. 2517-2533, 2023, DOI:10.32604/biocell.2023.043864 - 27 November 2023

Abstract Background: Various physiological mechanisms are linked to dilated cardiomyopathy (DCM) development, including oxidative stress, immune irregularities, inflammation, fibrosis, and genetic changes. However, precise molecular drivers of DCM, especially regarding abnormal immune responses, remain unclear. This study investigates immune-related long non-coding RNAs (lncRNAs) in DCM’s diagnostic and therapeutic potential. Methods: GSE141910, GSE135055, and GSE165303 datasets were acquired from the GEO database. LASSO, SVM-RFE, and random forest algorithms identified DCM-associated immune-related lncRNAs. Diagnostic capabilities were assessed by Nomogram and receiver operating characteristic (ROC) curves. Multivariate linear regression explored lncRNA correlations with ejection fraction. Single-sample gene set enrichment analysis… More > Graphic Abstract

Chao Luo¹, Canghong Shi¹, Xiaojie Li^{1, *}, Xin Wang⁴, Yucheng Chen³, Dongrui Gao¹, Youbing Yin⁴, Qi Song⁴, Xi Wu¹, Jiliu Zhou¹

CMC-Computers, Materials & Continua, Vol.63, No.2, pp. 995-1012, 2020, DOI:10.32604/cmc.2020.07968 - 01 May 2020

Abstract Myocardial segmentation and classification play a major role in the diagnosis of cardiovascular disease. Dilated Cardiomyopathy (DCM) is a kind of common chronic and life-threatening cardiopathy. Early diagnostics significantly increases the chances of correct treatment and survival. However, accurate and rapid diagnosis of DCM is still challenge due to high variability of cardiac structure, low contrast cardiac magnetic resonance (CMR) images, and intrinsic noise in synthetic CMR images caused by motion artifact and cardiac dynamics. Moreover, visual assessment and empirical evaluation are widely used in routine clinical diagnosis, but they are subject to high inter-observer… More >