Hailin Pang1, Ningqiang Ma1, Mi Jiao, Weiwei Shen, Bo Xin, Tongfei Wang, Feng Zhang, Lili Liu, Helong Zhang
Oncology Research, Vol.25, No.1, pp. 35-42, 2017, DOI:10.3727/096504016X14719078133249
Abstract The bone is among the most common sites of metastasis in patients with lung cancer. Over 30%–40% of lung
cancers can develop bone metastasis, and no effective therapeutic methods exist in clinic cases. Wnt/β-catenin
signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferentially
metastasizes to the skeleton. However, the role of DKK1 in osteotropism of small cell lung cancer (SCLC)
remains to be elucidated. This study aimed to define the role of DKK1 in SCLC bone metastasis and investigate the underlying mechanisms. Our results demonstrated that the expression level… More >
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