Xiaoyan Wang*, Yongguang Xu*, Xinlei Chen*, Jianmin Xiao†
Oncology Research, Vol.26, No.3, pp. 495-502, 2018, DOI:10.3727/096504017X14982578608217
Abstract This study aimed to investigate the effect of dexmedetomidine (DEX) on osteosarcoma (OS) cell line MG63
and to explore the possible relationship between DEX and miR-520-3p in OS. The results showed that DEX
could upregulate miR-520-3p, which directly targeted AKT1. Additionally, miR-520-3p also inhibited MG63
cell proliferation and migration, promoted apoptosis, and suppressed protein expressions of AKT, p-AKT,
p-mTOR, and p-ERK1/2. DEX can inhibit OS cell proliferation and migration and promote apoptosis by upregulating the expression level of miR-520a-3p. DEX may serve as a potential therapeutic agent in OS treatment,
and miR-520a-3p may be a More >
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