Jing Xiao*, Guang Li†, Jingyu Zhou‡, Shalong Wang‡, Dongcai Liu‡, Guoshun Shu‡, Jianping Zhou‡, Feng Ren‡
Oncology Research, Vol.26, No.4, pp. 593-604, 2018, DOI:10.3727/096504017X14920318811712
Abstract MicroRNAs (miRs), a class of small noncoding RNAs, are important regulators for gene expression through
directly binding to the 3'-untranslated region (3'-UTR) of their target mRNA. Recently, downregulation of
miR-520b has been observed in several common human cancers. However, the exact role of miR-520b in
colorectal cancer (CRC) has not previously been studied. In this study, our data showed that miR-520b was
significantly downregulated in CRC and cell lines when compared with adjacent normal tissues and a normal
intestinal epithelial cell line. Low expression of miR-520b was notably associated with the malignant progress
and a… More >
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