HAIQING HU^1,#,*, HAO YANG^2,#, SHUAISHUAI FAN³, XUE JIA³, YING ZHAO³, HONGRUI LI³

Oncology Research, Vol.32, No.8, pp. 1335-1346, 2024, DOI:10.32604/or.2024.044174 - 17 July 2024

Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >

HYUNHO KIM¹, UIJU CHO², SOOK HEE HONG³, HYUNG SOON PARK¹, IN-HO KIM³, HO JUNG AN¹, BYOUNG YONG SHIM¹, JIN HYOUNG KANG^3,*

Oncology Research, Vol.32, No.6, pp. 1021-1030, 2024, DOI:10.32604/or.2024.048919 - 23 May 2024

Abstract Background: Apolipoprotein B mRNA editing catalytic polypeptide (APOBEC), an endogenous mutator, induces DNA damage and activates the ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway. Although cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer (MIBC), it has a poor survival rate. Therefore, this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B (APOBEC3B) expressing MIBC. Methods: Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with MIBC. The APOBEC3B expression in MIBC cell lines was assessed… More >

FU-MING TSAI¹, PING-HSUN LU^2,3, LU-KAI WANG⁴, CHAN-YEN KUO¹, MAO-LIANG CHEN¹, CHUN-HUA WANG^5,6,*

BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093 - 28 August 2023

Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were… More >

TONG WANG^1,4,#, JINHUAN HONG^1,5,#, JIAJIE XIE^1,5, QIAN LIU⁴, JINRUI YUE^1,5, XUTING HE^1,5, SHIYU GE⁴, TAO LI⁴, GUOXIN LIU⁴, BENZHI CAI^1,3,5, LINQIANG LI^2,*, YE YUAN^1,3,5,*

BIOCELL, Vol.47, No.8, pp. 1811-1820, 2023, DOI:10.32604/biocell.2023.029120 - 28 August 2023

Abstract Background: Phototherapies based on sunlight, infrared, ultraviolet, visible, and laser-based treatments present advantages like high curative effects, small invasion, and negligible adverse reactions in cancer treatment. We aimed to explore the potential therapeutic effects of blue light emitting diode (LED) in human hepatoma cells and decipher the underlying cellular and molecular mechanisms. Methods: Wound healing and transwell assays were employed to probe the inhibition of the invasion and migration of hepatocellular carcinoma cells in the presence of blue LED. The sphere-forming test was used to evaluate the effect of LED blue light irradiation on cancer… More > Graphic Abstract

CHIWEN BU^1,2, LIGANG ZHAO¹, LISHAN WANG¹, ZEQIAN YU¹, JIAHUA ZHOU^1,*

Oncology Research, Vol.31, No.4, pp. 495-503, 2023, DOI:10.32604/or.2023.029309 - 25 June 2023

Abstract Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months, and conventional chemotherapeutics are the main treatment strategy. Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. Moreover, we found that knockdown of the More > Graphic Abstract

JIAMING ZHAN, WEIHUA WANG, YANLEI TANG, NING ZHOU, DAOWEN JIANG^*

BIOCELL, Vol.46, No.12, pp. 2601-2613, 2022, DOI:10.32604/biocell.2022.021300 - 10 August 2022

Abstract Esophageal cancer (EC) was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis. Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression. In this study, by comparing EC samples and normal samples, we found a total of 132 DDR expression with a significant difference. Moreover, we revealed higher expression of POLN, PALB2, ATM, PER1, TOP3B and lower expression of HMGB1, UBE2B were correlated to longer OS in EC. In addition, a prognostic risk score based on 7 DDR gene expression (POLN, HMGB1, TOP3B, PER1, UBE2B,… More >

Svetla P. Gateva^1,*, Gabriele Jovtchev¹, Tsveta V. Angelova¹, Tzvetana P. Nonova², Nikolay Tyutyundzhiev³, Elena G. Geleva², Kostadin Katrandzhiev¹, Nina A. Nikolova², Dimitar Dimitrov⁴, Christo V. Angelov²

Phyton-International Journal of Experimental Botany, Vol.91, No.2, pp. 293-313, 2022, DOI:10.32604/phyton.2022.016397 - 26 September 2021

Abstract Plants in natural ecosystems are exposed to a combination of UV radiation, ionizing radiation (IR) and other abiotic factors. These factors change with the altitude. We investigated DNA alterations of some wild plants of different plant families in natural ecosystems at three altitudes in Rila Mountain, Bulgaria (1500, 1782, and 2925 m above sea level (a.s.l.) exposed to UV radiation, IR and other abiotic stresses, to assess the tolerance of plant species to the changing environmental conditions in three successive growth seasons. For this purpose, physicochemical, cytogenetic, and molecular methods were applied. DNA damage was assessed… More >

BIN LIU^1,2,#, HAIPENG LIU^3,#, FEIFEI REN^1,2, HANGFAN LIU¹, IHTISHAM BUKHARI¹, YUMING FU⁴, WANQING WU⁴, MINGHAI ZHAO⁵, SHAOGONG ZHU⁶, HUI MO¹, FAZHAN LI^1,2, MICHAEL B. ZHENG⁷, YOUCAI TANG^1,2, PENGYUAN ZHENG^1,2,*, YANG MI^1,2,*

Oncology Research, Vol.29, No.2, pp. 87-103, 2021, DOI:10.32604/or.2022.03529 - 13 July 2022

Abstract The activation of some oncogenes promote cancer cell proliferation and growth, facilitate cancer progression and metastasis by induce DNA replication stress, even genome instability. Activation of the cyclic GMP-AMP synthase (cGAS) mediates classical DNA sensing, is involved in genome instability, and is linked to various tumor development or therapy. However, the function of cGAS in gastric cancer remains elusive. In this study, the TCGA database and retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and cell lines. By employing cGAS high-expression gastric cancer cell lines, including AGS and MKN45, ectopic silencing… More >

Mohammed Ali Ashehri^*

Phyton-International Journal of Experimental Botany, Vol.90, No.6, pp. 1749-1762, 2021, DOI:10.32604/phyton.2021.016290 - 28 June 2021

Abstract In most of Arabian courtiers Rhazya stricta is extensively utilized in public medicine for several diseases treatment. In this study, crude alkaloid extract of R. stricta (CAERS) coated with silver nanoparticles (CAERS-AgNPs) as potential treatment against diabetes in DM animal model was evaluated. Swiss albino male rats (n = 80) were injected with STZ to induce Diabetes Mellitus type-2 (DM). DM-rats were injected different doses of CAERS or CAERS-nanoparticles (CAERS-NPs) for 2 months. The results exhibited that mRNA expression of insulin and insulin receptor was down-regulated, activity levels of antioxidant enzymes were decreased, generation of ROS mediated DNA adducts… More >

Annemarie E. M. Post^*†, Johan Bussink^*, Fred C. G. J. Sweep^†, Paul N. Span^*

Oncology Research, Vol.28, No.1, pp. 33-40, 2020, DOI:10.3727/096504019X15555794826018

Abstract Tamoxifen-induced radioresistance, reported in vitro, might pose a problem for patients who receive neoadjuvant tamoxifen treatment and subsequently receive radiotherapy after surgery. Previous studies suggested that DNA damage repair or cell cycle genes are involved, and could therefore be targeted to preclude the occurrence of cross-resistance. We aimed to characterize the observed cross-resistance by investigating gene expression of DNA damage repair genes and cell cycle genes in estrogen receptor-positive MCF-7 breast cancer cells that were cultured to tamoxifen resistance. RNA sequencing was performed, and expression of genes characteristic for several DNA damage repair pathways was… More >