Naoki Katase*†, Shin-Ichiro Nishimatsu†‡, Akira Yamauchi§, Masahiro Yamamura¶, Kumiko Terada†‡, Masumi Itadani§, Naoko Okada¶#, Nur Mohammad Monsur Hassan**, Hitoshi Nagatsuka††,
Tohru Ikeda*‡‡, Tsutomu Nohno†, Shuichi Fujita*
Oncology Research, Vol.26, No.1, pp. 45-58, 2018, DOI:10.3727/096504017X14926874596386
Abstract DKK3, a member of the dickkopf Wnt signaling pathway inhibitor family, is believed to be a tumor suppressor because of its reduced expression in cancer cells. However, our previous studies have revealed that DKK3
expression is predominantly observed in head and neck/oral squamous cell carcinoma (HNSCC/OSCC).
Interestingly, HNSCC/OSCC patients with DKK3 expression showed a high rate of metastasis and poorer
survival, and siRNA-mediated knockdown of DKK3 in HNSCC-derived cancer cell lines resulted in reduced
cellular migration and invasion. From these data, it was hypothesized that DKK3 might exert an oncogenic
function specific to HNSCC. In… More >
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