Ye Lou*1, Lei Liu†1, Lihui Zhan‡, Xuewei Wang§, Hua Fan¶
Oncology Research, Vol.24, No.2, pp. 89-97, 2016, DOI:10.3727/096504016X14597766487753
Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of
mortality in affected adults. Many subtypes of ALL exist with disruptions in distinct genetic pathways, including those regulated by miRNAs. Here we identify miR-187-5p as being highly upregulated in B-cell ALL and
a driver of cellular proliferation and suppressor of apoptosis. We show that miR-187-5p directly targets the
3'-UTR of DKK2 to mediate these effects. We further determine that inhibition of DKK2 by miR-187-5p in
Nalm-6 B cells leads to inappropriate activation of Wnt/β-catenin signaling. Together, these findings reveal More >
Login
Register
