Abdulrahman K. Sinno¹, Aisha Mustapha¹, Navya Nair¹, Simona Zaami², Lina De Paola², Valentina Billone³, Eleonora Conti³, Giuseppe Gullo^3,*, Pasquale Patrizio⁴

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072176 - 30 December 2025

Abstract Cervical cancer related to human papillomavirus (HPV) is a leading cause of cancer-related mortality among women worldwide. Cancer cells release fragments of their DNA, known as circulating tumor DNA (ctDNA), which can be detected in bodily fluids. A PubMed search using the terms “ctHPV” or “circulating tumor DNA” and “cervical cancer”, limited to the past ten years, identified 104 articles, complemented by hand-searching for literature addressing medico-legal implications. Studies were evaluated for relevance and methodological quality. Detection and characterization of circulating tumor HPV DNA (ctHPV DNA) have emerged as promising tools for assessing prognosis and More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

Tao Zhu¹, Taofeng Wei¹, Mingdong Yang¹, Junjun Xu¹, Huifang Jiang¹, Wei He¹, Juyan Zheng^2,*, Haibin Dai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070180 - 30 December 2025

Abstract Background: Aberrant expression of transcription factors (TFs) is a key mechanism mediating tumor immune escape and therapeutic resistance. The involvement of E26 transformation-specific (ETS) family of TFs in immune regulation is not fully understood. The study aimed to elucidate the function of E-twenty-six variant 4 (ETV4) in tumor immune evasion and its potential as a predictive biomarker for immunotherapy in melanoma. Methods: The expression patterns of ETS family TFs were analyzed in melanoma and hepatocellular carcinoma (HCC). Single-cell RNA sequencing (scRNA-seq) was used to dissect the cellular expression and function of ETV4 in the tumor… More >

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Hongyu Wang¹, Wenwu Cui¹, Kai Cui¹, Zixuan Meng^2,*, Bin Li², Wei Zhang¹, Wenwen Li¹

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.069576 - 27 December 2025

Abstract To achieve low-carbon regulation of electric vehicle (EV) charging loads under the “dual carbon” goals, this paper proposes a coordinated scheduling strategy that integrates dynamic carbon factor prediction and multi-objective optimization. First, a dual-convolution enhanced improved Crossformer prediction model is constructed, which employs parallel 1 × 1 global and 3 × 3 local convolution modules (Integrated Convolution Block, ICB) for multi-scale feature extraction, combined with an Adaptive Spectral Block (ASB) to enhance time-series fluctuation modeling. Based on high-precision predictions, a carbon-electricity cost joint optimization model is further designed to balance economic, environmental, and grid-friendly objectives.… More > Graphic Abstract

Tahira Khalil¹, Sadeeq Jan^2,*, Rania M. Ghoniem³, Muhammad Imran Khan Khalil¹

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-20, 2026, DOI:10.32604/cmc.2025.072655 - 09 December 2025

Abstract The contemporary era is characterized by rapid technological advancements, particularly in the fields of communication and multimedia. Digital media has significantly influenced the daily lives of individuals of all ages. One of the emerging domains in digital media is the creation of cartoons and animated videos. The accessibility of the internet has led to a surge in the consumption of cartoons among young children, presenting challenges in monitoring and controlling the content they view. The prevalence of cartoon videos containing potentially violent scenes has raised concerns regarding their impact, especially on young and impressionable minds.… More >

Guangyu Huo, Chang Su, Xiaoyu Zhang^*, Xiaohui Cui, Lizhong Zhang

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-23, 2026, DOI:10.32604/cmc.2025.072147 - 09 December 2025

Abstract Long-term traffic flow prediction is a crucial component of intelligent transportation systems within intelligent networks, requiring predictive models that balance accuracy with low-latency and lightweight computation to optimize traffic management and enhance urban mobility and sustainability. However, traditional predictive models struggle to capture long-term temporal dependencies and are computationally intensive, limiting their practicality in real-time. Moreover, many approaches overlook the periodic characteristics inherent in traffic data, further impacting performance. To address these challenges, we introduce ST-MambaGCN, a State-Space-Based Spatio-Temporal Graph Convolution Network. Unlike conventional models, ST-MambaGCN replaces the temporal attention layer with Mamba, a state-space More >

Qun Song¹, Chao Gao¹, Han Wu¹, Zhiheng Rao¹, Huafeng Qin^1,*, Simon Fong^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-49, 2026, DOI:10.32604/cmc.2025.070918 - 09 December 2025

Abstract Metaheuristic algorithms, renowned for strong global search capabilities, are effective tools for solving complex optimization problems and show substantial potential in e-Health applications. This review provides a systematic overview of recent advancements in metaheuristic algorithms and highlights their applications in e-Health. We selected representative algorithms published between 2019 and 2024, and quantified their influence using an entropy-weighted method based on journal impact factors and citation counts. CThe Harris Hawks Optimizer (HHO) demonstrated the highest early citation impact. The study also examined applications in disease prediction models, clinical decision support, and intelligent health monitoring. Notably, the More >

Longyue Li¹, Guoqing Zhang¹, Bo Cao¹, Shuqi Wang², Ye Tian^1,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-26, 2026, DOI:10.32604/cmc.2025.070622 - 09 December 2025

Abstract Modern battlefields exhibit high dynamism, where traditional static weighting methods in combat effectiveness assessment fail to capture real-time changes in indicator values, leading to limited assessment accuracy—especially critical in scenarios like sudden electronic warfare or degraded command, where static weights cannot reflect the operational value decay or surge of key indicators. To address this issue, this study proposes a dynamic adaptive weighting method for evaluation indicators based on G1-CRITIC-PIVW. First, the G1 (Sequential Relationship Analysis Method) subjective weighting method—translates expert knowledge into indicator importance rankings—leverages expert knowledge to quantify the relative importance of indicators via… More >

Himadri Nath Saha¹, Dipanwita Chakraborty Bhattacharya^2,*, Sancharita Dutta³, Arnab Bera³, Srutorshi Basuray⁴, Satyasaran Changdar⁵, Saptarshi Banerjee⁶, Jon Turdiev⁷

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-56, 2026, DOI:10.32604/cmc.2025.070507 - 09 December 2025

Abstract The emergence of Medical Large Language Models has significantly transformed healthcare. Medical Large Language Models (Med-LLMs) serve as transformative tools that enhance clinical practice through applications in decision support, documentation, and diagnostics. This evaluation examines the performance of leading Med-LLMs, including GPT-4Med, Med-PaLM, MEDITRON, PubMedGPT, and MedAlpaca, across diverse medical datasets. It provides graphical comparisons of their effectiveness in distinct healthcare domains. The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making, documentation, drug discovery, research, patient interaction, and public health. The paper addresses deployment challenges of Medical-LLMs, More >