Rasit Dinc¹, Nurittin Ardic^2,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072337 - 23 January 2026

Abstract Neutrophil extracellular traps (NETs) have emerged as key mediators of cardiovascular diseases (CVDs), linking innate immune activation to vascular injury, thrombosis, and maladaptive remodeling. This review synthesizes recent insights into the molecular and cellular pathways driving NET formation, including post-translational modifications, metabolic reprogramming, inflammasome signaling, and autophagy. It highlights the role of NETs in atherosclerosis, thrombosis, myocardial ischemia-reperfusion injury, and hypertension, emphasizing common control points such as peptidylarginine deiminase 4 (PAD4)-dependent histone citrullination and nicotinamide adenine dinucleotide phosphate oxidases 2 (NOX2)-mediated oxidative stress. Mechanistic interpretation of circulating biomarkers, including myeloperoxidase (MPO)-DNA complexes, citrullinated histone H3,… More >

Jingfa Li¹, Daobing Wang¹, Bo Yu^1,*, Shuyu Sun², Dongliang Sun¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.23, No.1, pp. 3-3, 2021, DOI:10.32604/icces.2021.08209

Abstract In natural gas engineering, the numerical simulation plays a significant role in the exploration, production and optimization of natural gas reservoir. However, numerical simulations of compressible gas flow in porous media are always expensive due to the gas compressibility and nonlinear properties. To save the computational cost, in this work we present a multigrid coupled discrete empirical interpolation method (MG-DEIM) to speedup the simulation of compressible gas porous flow. In this MG-DEIM framework, the core idea is that the multigrid method based on the full approximate scheme (FAS) is used to solve the flow equation… More >

Jingfa Li^1,2, Shuyu Sun^2,*, Bo Yu¹, Yang Liu², Tao Zhang²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.3, pp. 141-142, 2019, DOI:10.32604/icces.2019.04721

Abstract The multiphase fluid flow in porous media is one of the most fundamental phenomena in various physical processes, such as oil/gas flow in reservoir, subsurface contamination dispersion, chemical separation, etc. Due to its importance, the efficient and accurate solution and prediction of multiphase flow in porous media is highly required in engineering applications and mechanism studies, which has been a research hot spot with increasing interest in recent years. However, the strong nonlinearity implicated in the multiphase flow model has brought great challenges for the computation and analysis. In addition, the permeability in Darcy-type pressure… More >

Sylvie Ferrari-Lacraz¹, Mireille Sebbag^2,3,4, Rachel Chicheportiche¹, Céline Foulquier^3,4, Guy Serre^2,3,4,5, Jean-Michel Dayer⁶

European Cytokine Network, Vol.23, No.2, pp. 36-44, 2012, DOI:10.1684/ecn.2012.0303

Abstract Objective: The antigenic targets of the rheumatoid arthritis (RA)-associated autoantibodies to “citrullinated” proteins are generated following citrullination by a peptidylarginine deiminase (PAD). Of the five PAD isotypes, two – PAD2 and PAD4 – are expressed in RA synovial tissue. Within this tissue, the activation of macrophages and fibroblasts mediated by T-cell contact or driven by cytokines plays a prominent part in the pathogenesis. We wanted to determine whether cytokine stimulation and contact with T cells could play a role in PAD expression by peripheral blood monocytes and fibroblastic synoviocytes. Methods: Human monocytes and T lymphocytes… More >