Feng Jiang1, Dengfeng Zhang1, Guojun Li, Xiao Wang
Oncology Research, Vol.25, No.3, pp. 417-425, 2017, DOI:10.3727/096504016X14747253292210
Abstract DDX46, a member of the DEAD-box (DDX) helicase family, is involved in the development of several tumors.
However, the exact role of DDX46 in osteosarcoma and the underlying mechanisms in tumorigenesis remain
poorly understood. Thus, in the present study, we explored the role of DDX46 in osteosarcoma and the underlying mechanisms. Our results demonstrated that the expression levels of DDX46 in both mRNA and protein
were greatly elevated in human osteosarcoma tissues and cell lines. Knockdown of DDX46 obviously inhibited
osteosarcoma cell proliferation and tumor growth in vivo. In addition, knockdown of DDX46 also significantly More >
Login
Register
