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  • Open Access

    ARTICLE

    Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

    HYUNG SUN KIM1,#, YUN SUN LEE2,#, SEUNG MYUNG DONG3, HYO JUNG KIM1, DA EUN LEE2, HYEON WOONG KANG2, MYEONG JIN KIM2, JOON SEONG PARK1,*

    Oncology Research, Vol.32, No.4, pp. 615-624, 2024, DOI:10.32604/or.2024.044029

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies. A specific mechanism of its metastasis has not been established. In this study, we investigated whether Neural Wiskott-Aldrich syndrome protein (N-WASP) plays a role in distant metastasis of PDAC. We found that N-WASP is markedly expressed in clinical patients with PDAC. Clinical analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group. N-WASP was noted to be a novel mediator of epithelial-mesenchymal transition (EMT) via gene expression profile studies. Knockdown of N-WASP in pancreatic cancer cells significantly inhibited cell invasion, migration,… More > Graphic Abstract

    Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

  • Open Access

    ARTICLE

    Transcriptome-Wide Identification and Functional Analysis of PgSQE08-01 Gene in Ginsenoside Biosynthesis in Panax ginseng C. A. Mey.

    Lei Zhu1,#, Lihe Hou1,3,#, Yu Zhang1, Yang Jiang1, Yi Wang1,2, Meiping Zhang1,2, Mingzhu Zhao1,2,*, Kangyu Wang1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 313-327, 2024, DOI:10.32604/phyton.2024.047938

    Abstract Panax ginseng C. A. Mey. is an important plant species used in traditional Chinese medicine, whose primary active ingredient is a ginsenoside. Ginsenoside biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural genes. Nonetheless, the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary metabolites. Squalene epoxidase (SQE) is a key enzyme in the mevalonic acid pathway, which affects the biosynthesis of secondary metabolites such as terpenoid. Using ginseng transcriptome, expression, and ginsenoside content databases, this study employed bioinformatic methods to systematically analyze the genes encoding… More >

  • Open Access

    REVIEW

    Extracellular vesicles and angiotensin-converting enzyme 2 in COVID-19 disease

    YU LIU*, ROBERT J. KASPER, NATALIE J. S. CHOI*

    BIOCELL, Vol.48, No.1, pp. 1-8, 2024, DOI:10.32604/biocell.2023.031158

    Abstract Extracellular vesicles (EVs) are membranous vesicular structures released from almost all eukaryotic cell types under different physiological or pathological conditions. Growing evidence demonstrates that EVs can serve as mediators of intercellular communication between donor and recipient cells or microorganism-infected and noninfected cells. Coronavirus disease 2019 (COVID-19) disease is caused by infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of host cells in the respiratory system and various extra-pulmonary tissue/organs, resulting in complications of multiple organ systems. As the cell surface receptor, angiotensin-converting enzyme 2 (ACE2) mediates cellular entry of SARS-CoV-2 into the host cells in patients with COVID-19.… More >

  • Open Access

    ARTICLE

    Radiative Blood-Based Hybrid Copper-Graphene Nanoliquid Flows along a Source-Heated Leaning Cylinder

    Siti Nur Ainsyah Ghani1, Noor Fadiya Mohd Noor1,2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 1017-1037, 2024, DOI:10.32604/cmes.2023.031372

    Abstract Variant graphene, graphene oxides (GO), and graphene nanoplatelets (GNP) dispersed in blood-based copper (Cu) nanoliquids over a leaning permeable cylinder are the focus of this study. These forms of graphene are highly beneficial in the biological and medical fields for cancer therapy, anti-infection measures, and drug delivery. The non-Newtonian Sutterby (blood-based) hybrid nanoliquid flows are generalized within the context of the Tiwari-Das model to simulate the effects of radiation and heating sources. The governing partial differential equations are reformulated into a nonlinear set of ordinary differential equations using similar transformational expressions. These equations are then transformed into boundary value problems… More >

  • Open Access

    ARTICLE

    Evaluation of combined detection of nuclear factor erythroid 2-related factor 2 and glutathione peroxidase 4 in primary hepatic carcinoma and preliminary exploration of pathogenesis

    JIE DUAN, AIDONG GU*, WEI CHEN, CHANGHAO CHEN, FANGNAN SONG, FAXI CHEN, FANGFANG JIANG, HUIWEN XING

    BIOCELL, Vol.47, No.12, pp. 2609-2615, 2023, DOI:10.32604/biocell.2023.042472

    Abstract Objective: This study aims to analyze the clinical significance and mechanism of nuclear factor erythroid 2-related factor 2 (NRF2) and glutathione peroxidase 4 (GPX4) in primary hepatic carcinoma (PHC). Methods: The expression of NRF2 and GPX4 in peripheral blood of patients with PHC was determined to analyze the diagnostic value of the two combined for PHC. The prognostic significance of NRF2 and GPX4 was evaluated by 3-year follow-up. Human liver epithelial cells THLE-2 and human hepatocellular carcinoma cells HepG2 were purchased, and the expression of NRF2 and GPX4 in the cells was determined. NRF2 and GPX4 aberrant expression vectors were… More > Graphic Abstract

    Evaluation of combined detection of nuclear factor erythroid 2-related factor 2 and glutathione peroxidase 4 in primary hepatic carcinoma and preliminary exploration of pathogenesis

  • Open Access

    ARTICLE

    Widely Untargeted Metabolome Profiling Provides Insight into Browning and Nutritional Quality Changes in Short-Term Stored Fresh-Cut Potato (Solanum tuberosum L.) Shreds

    Liping Hong, Enming He, Wenhui Zhang, Mingqiong Zheng, Jingwen Wu, Wenhua Wang*

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2785-2805, 2023, DOI:10.32604/phyton.2023.030928

    Abstract Potato (Solanum tuberosum L.) is susceptible to enzymatic browning after fresh processing, resulting in color change and potential alteration in the nutritional quality. In this study, a popular potato cultivar, Feiwuruita, was used to profile the metabolites involved in color and nutritional quality changes in fresh shreds stored at 0 and 4 h at 25°C (designated CK and CK4H, respectively). The shreds turned brown within 4 h of storage. In all, 723 metabolites consisting 12 classes of compounds were detected in the samples, largely lipids, phenolic acids, alkaloids, amino acids and derivatives, flavonoids, organic acids, nucleotides and derivatives. Of these,… More >

  • Open Access

    ARTICLE

    Effects of Plant Extracts and Beauveria bassiana on the Activity of Defense-Related Enzymes in Solanum lycopersicum L. during Interaction with Fusarium oxysporum f. sp. lycopersici

    José Adrian Perez-Robles, Carlos Alberto Lecona-Guzmán*, Víctor Manuel Ruíz-Valdiviezo, Joaquín Adolfo Montes-Molina*

    Phyton-International Journal of Experimental Botany, Vol.92, No.9, pp. 2503-2518, 2023, DOI:10.32604/phyton.2023.029784

    Abstract The objective to this work was to evaluate the enzymatic activity in the culture of Solanum lycopersicum L. infected with Fusarium oxysporum after the combined application of Beauveria bassiana and plant extracts. Solanum lycopersicum plantlets were transplanted 15 days after the emergency. Five days after transplanting, Beauveria bassiana spores were applied at a concentration of 1 × 107 spores mL−1 onto soil (along with A. indica (N) and P. auritum (H) leaf extracts) where S. lycopersicum plants were planted. Eight days after transplanting, spores of F. oxysporum strain were applied at a concentration of 1 × 106 spores mL−1 to… More >

  • Open Access

    ARTICLE

    The Improvement of Soybean Salt Tolerance by Overexpressed GmPAO1

    Yeyao Du, Yang Song, Ye Zhang, Sujie Fan, Hanzhu Zhang, Piwu Wang*

    Phyton-International Journal of Experimental Botany, Vol.92, No.4, pp. 1109-1124, 2023, DOI:10.32604/phyton.2023.025503

    Abstract Polyamines play an important regulatory role during plant growth and development and adversity stress, and polyamine oxidase (PAO) is involved in polyamine catabolism. In this study, an up-regulated polyamine oxidase gene GmPAO1 was obtained by transcriptome sequencing analysis and screening at soybean seedling stages. Also, its expression pattern and function were analyzed. The identification results of transgenic GmPAO1 soybean positive lines showed that the relative expression level of GmPAO1 in the overexpressed lines was increased under salt stress. With increasing stress concentration, the seed germination rate decreased. However, the seed germination rate of the overexpressed lines was significantly higher than… More >

  • Open Access

    ARTICLE

    Investigating the Retrofit of RC Frames Using TADAS Yielding Dampers

    Mehrzad TahamouliRoudsari1,*, K. Cheraghi2, R. Aghayari2

    Structural Durability & Health Monitoring, Vol.16, No.4, pp. 343-359, 2022, DOI:10.32604/sdhm.2022.07927

    Abstract TADAS dampers are a type of passive structural control system used in the seismic design or retrofitting of structures. These types of dampers are designed so that they would yield before the main components of the structure during earthquake. This dissipates a large portion of the earthquake’s energy and reduces the energy dissipation demand in the main components of the structure. Considering its suitable performance, this damper has been the subject of numerous studies. However, there are still ambiguities regarding the effect of the number of these dampers on the retrofitting of reinforced concrete (RC) frames and their design procedure.… More >

  • Open Access

    ARTICLE

    NOTCH3 Mutations and CADASIL Phenotype in Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

    Rui Jiang1,3,*, Kaisheng Lai2, Jianping Xu1, Xiang Feng1, Shaoye Wang1, Xiaojian Wang3, Zhe Liu2

    Congenital Heart Disease, Vol.17, No.6, pp. 675-686, 2022, DOI:10.32604/chd.2022.021626

    Abstract Background: The etiology of pulmonary arterial hypertension associated with congenital heart disease (PAHCHD) is complicated and the phenotype is heterogeneous. Genetic defects of NOTCH3 were associated with cerebral disease and pulmonary hypertension. However, the relationship between NOTCH3 mutations and the clinical phenotype has not been reported in CHD-PAH. Methods: We eventually enrolled 142 PAH-CHD patients from Fuwai Hospital. Whole exome sequencing (WES) was performed to screen the rare deleterious variants of NOTCH3 gene. Results: This PAH-CHD cohort included 43 (30.3%) men and 99 (69.7%) women with the mean age 29.8 ± 10.9 years old. The pathogenic or likely pathogenic mutations… More >

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