ANGELES C. TECALCO-CRUZ^*

BIOCELL, Vol.46, No.5, pp. 1209-1213, 2022, DOI:10.32604/biocell.2022.018136 - 06 January 2022

Abstract Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. Cytoskeletal dynamics are modulated by matrix proteins, integrins, and several cytokines in the tumor microenvironment. In this scenario, signaling is activated by integrins and interferons, which can induce ISG15 gene expression. This gene encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation system. Furthermore, non-conjugated ISG15 acts as a cytokine-like protein. In this viewpoint, the interplay between free ISG15, protein ISGylation, and cytoskeletal dynamics in the tumor microenvironment is discussed. More >

M. CAROLINA DI SANTO^1,2,#, AGUSTINA ALAIMO^1,2,#, ANA PAULA DOMÍNGUEZ RUBIO^1,2, OSCAR E. PÉREZ^1,2,*

BIOCELL, Vol.46, No.4, pp. 885-891, 2022, DOI:10.32604/biocell.2022.018391 - 15 December 2021

Abstract Chitosan-based nanocarriers (CS-NCs) show a promising role in improving drugs and bioactive compounds delivery for therapy. However, the effects exerted by CS-NCs at the cellular level, including their recognition and uptake, have not been fully investigated yet. Many factors, including size, shape, concentration, and surface chemistry of CS-NCs, play an important role in determining the types of intracellular signals triggered. The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells. In the present work, we discuss the… More >