Tong Li∗, Prasad KDV Yarlagadda∗, Adekunle Oloyede∗, Namal Thibbotuwawa∗, YuanTong Gu∗,†
Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 17-35, 2015, DOI:10.3970/mcb.2015.012.017
Abstract Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated dynamic cellular processes. Fortunately, multiscale modelling provides a powerful simulation tool that can be used to study the mechanical properties of these soft hierarchical, biological systems. This paper reviews recent developments in hierarchical multiscale modeling technique that aimed at understanding cytoskeleton mechanics. Discussions are expanded with respects to cytoskeletal components including: intermediate filaments, microtubules and microfilament networks. The mechanical performance More >
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