KHAWAR ALI SHAHZAD1,2,#, ZHONGJIE QIN3,4,#, YAN LI1,2,*, DELIN XIA3,4,*
BIOCELL, Vol.44, No.2, pp. 137-145, 2020, DOI:10.32604/biocell.2020.08500
- 27 May 2020
Abstract Focal adhesions are polyproteins linked to extracellular matrix and cytoskeleton, which play an important role
in the process of transforming force signals into intracellular chemical signals and subsequently triggering related
physiological or pathological reactions. The cytoskeleton is a network of protein fibers in the cytoplasm, which is
composed of microfilaments, microtubules, intermediate filaments, and cross-linked proteins. It is a very important
structure for cells to maintain their basic morphology. This review summarizes the process of fluid shear stress
transduction mediated by focal adhesion and the key role of the cytoskeleton in this process, which focuses More >
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