Haiyan Jia*, Hong Wang†, Yanfen Yao*, Chunlei Wang‡, Pibao Li*
Oncology Research, Vol.26, No.6, pp. 967-976, 2018, DOI:10.3727/096504018X15148192843443
Abstract MicroRNAs (miRNAs) play a vital role in regulating tumor progression. Dysregulated miR-136 expression
was linked to the development of various human cancers. In the present study, we investigated the expression
and relationship of miR-136 and COX2 in hepatocellular carcinoma (HCC) using relevant experiments, involving CCK-8, Transwell assay, and luciferase reporter assay. We demonstrated that miR-136 expression is obviously decreased in HCC tissues and cells, and negatively correlated with the expression of COX2 mRNA. In
vitro assay revealed that overexpression of miR-136 significantly changed the expression of proliferation- and
metastasis-related proteins and inhibited the proliferation, migration, More >
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