Zheng-Gang Chen^*, Chuan-Yi Zheng^*, Wang-Qing Cai^†, Da-Wei Li^*, Fu-Yue Ye^*, Jian Zhou^*, Ran Wu^*, Kun Yang^*

Oncology Research, Vol.27, No.2, pp. 147-155, 2019, DOI:10.3727/096504017X15021536183517

Abstract Glioma is the most common malignant tumor of the nervous system. Studies have shown the microRNA-26b (miR-26b)/cyclooxygenase-2 (COX-2) axis in the development and progression in many tumor cells. Our study aims to investigate the effect and mechanism of the miR-26b/COX-2 axis in glioma. Decreased expression of miR-26b with increased levels of COX-2 was found in glioma tissues compared with matched normal tissues. A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. The miR-26b was then overexpressed by transfecting a miR-26b mimic into U-373 cells. The invasive cell More >

Xiaoyun Liu¹, Shuguang Li¹, Yanyan Li, Bo Cheng, Bo Tan, Gang Wang

Oncology Research, Vol.26, No.8, pp. 1227-1234, 2018, DOI:10.3727/096504018X15178736525106

Abstract Bladder cancer (BC) is a common disease of the urinary system. Puerarin is a flavonoid extracted from Pueraria lobata. However, the role of puerarin in BC remains unclear. Hence, this study aimed to investigate the effect of puerarin on BC cells. Cell viability, proliferation, and apoptosis were measured by CCK-8, BrdU assay, and flow cytometry analysis, respectively. The expressions of miR-16, apoptosis-related factors, and the main factors of the NF-kB pathway were analyzed by qRT-PCR and Western blot. In this study, we found that cell viability and proliferation were significantly reduced, cell apoptosis was enhanced, and… More >