GARIMA SINGH#, SONIKA KUMARI SHARMA#, NEELU MISHRA, AASTHA SONI, MANSHI KUMARI, SAMARENDRA KUMAR SINGH*
BIOCELL, Vol.48, No.12, pp. 1639-1666, 2024, DOI:10.32604/biocell.2024.056503
- 30 December 2024
Abstract Dysregulation of the cell cycle is a molecular hallmark of cancer, which leads to uncontrolled proliferation and self-renewal of neoplastic cells. To maintain this phenotype, cells acquire multiple molecular alterations and bypass several cellular checkpoints that are involved in the prevention of genomic instability and uncontrolled cell proliferation. Therefore, targeting cell cycle regulators could prove to be a promising anti-cancer approach. Recent advancements in the understanding of cancer cell susceptibilities have revealed a therapeutic opportunity to selectively target the cell cycle in malignant cells. This review highlights major cell cycle dysregulation in cancerous cells and More >
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