Fengyu Huang*†, Hongjun Zhao†, Zhaojin Du‡, Hong Jiang§
Oncology Research, Vol.27, No.3, pp. 293-299, 2019, DOI:10.3727/096504018X15190399381143
Abstract Previous studies have reported that miR-615 exerts a tumor suppressor role in some tumors, such as esophageal
squamous cell carcinoma and non-small cell lung cancer. However, the role of miR-615 in prostate cancer has
not been defined. Here we found that miR-615 was downregulated in prostate cancer tissues and cell lines.
Overexpression of miR-615 in PC-3 cells significantly inhibited cellular proliferation, migration, and invasion.
Moreover, overexpression of miR-615 delayed tumor growth in vivo. In terms of mechanism, we found that
cyclin D2 (CCND2) is a target gene of miR-615 in prostate cancer. We showed that More >
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