Fangjin Lu*†, Ying Zheng‡, Paul Owusu Donkor*, Peng Zou§, Ping Mu†
Oncology Research, Vol.24, No.3, pp. 171-179, 2016, DOI:10.3727/096504016X14634208142987
Abstract The cyclic-AMP response element-binding protein (CREB), a well-known nuclear transcription factor, has
been shown to play an essential role in many cellular processes, including differentiation, cell survival, and cell
proliferation, by regulating the expression of downstream genes. Recently, increased expression of CREB was
frequently found in various tumors, indicating that CREB is implicated in the process of tumorigenesis. However,
the effects of CREB on Hodgkin lymphoma (HL) remain unknown. To clarify the role of CREB in HL, we performed knockdown experiments in HL. We found that downregulation of CREB by short hairpin RNA (shRNA)
resulted… More >
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