Sheng Li*1, Guoren Zhou*1, Wei Liu†, Jinjun Ye†, Fangliang Yuan‡, Zhi Zhang‡
Oncology Research, Vol.28, No.7-8, pp. 685-700, 2020, DOI:10.3727/096504020X15917007265498
Abstract Curcumol (Cur), isolated from the Traditional Chinese Medical plant Rhizoma Curcumae, is the bioactive
component of sesquiterpene reported to possess antitumor activity. However, its bioactivity and mechanisms
against lung adenocarcinoma are still unclear. We investigated its effect on lung adenocarcinoma and elucidated its underlying molecular mechanisms. In vitro, Cur effectively suppressed proliferation, migration, and
invasion of lung adenocarcinoma cells A549 and H460, which were associated with the altered expressions of
signaling molecules, including p-AKT, p-PI3K, p-LRP5/6, AXIN, APC, GSK3 and p- -catenin, matrix metalloproteinase (MMP)-2, and MMP-9. Furthermore, Cur significantly induced cell apoptosis of A549 and H460
by promoting the… More >
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