FEI SHA¹, DAISHAN XIN², JUN XU³, ZHIWEI ZHENG¹, WENXIN LIN¹, XIAORUI CAI¹, FEI LIN³, MINGHAO ZHENG^1,*, JIAOLING CHEN^1,*

BIOCELL, Vol.48, No.3, pp. 443-451, 2024, DOI:10.32604/biocell.2023.029188 - 15 March 2024

Abstract Background: Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer (CRC). However, as the molecular mechanism associated is still unclear, our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC. Methods: HT29 and SW480 cells were treated with curcumin or/and Doxycycline (DOX), and cell viability, colony forming ability, migration and invasion were confirmed by cell counting kit-8 (CCK-8), colony forming, Transwell assays. And Yes-associated protein 1 (YAP) and PDZ-binding motif (TAZ) signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR (RT-qPCR), western More > Graphic Abstract

AMYLLY SANUELLY DA PAZ MARTINS^1,#, MARLA DE CERQUEIRA ALVES^2,#, ORLANDO ROBERTO PIMENTEL DE ARAÚJO³, FABIANA OLIVEIRA DOS SANTOS CAMATARI⁴, MARÍLIA OLIVEIRA FONSECA GOULART^1,3,5, FABIANA ANDRÉA MOURA^2,6,*

BIOCELL, Vol.47, No.11, pp. 2547-2566, 2023, DOI:10.32604/biocell.2023.043253 - 27 November 2023

Abstract

Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with a multitude of factors linked to Inflammatory Bowel Disease (IBD). These factors encompass cytokines, oxidative stress-associated enzymes, and modulation of the intestinal microbiota. Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and β-catenin. Moreover, it inhibits the expression of pro-inflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic

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RAHAT ALI¹, AFTAB ALAM², SATYENDRA K. RAJPUT³, RAZI AHMAD^4,*

BIOCELL, Vol.46, No.12, pp. 2681-2694, 2022, DOI:10.32604/biocell.2022.021224 - 10 August 2022

Abstract Parkinson’s disease (PD) is an age-related neurodegenerative ailment that affects dopamine-producing neurons in a specific area of the brain called the substantia nigra of the ventral midbrain. It is clinically characterized by movement disorder and marked with unusual synaptic protein alpha-synuclein accumulation in the brain. To date, only a few Food and Drug Administration (FDA) approved drugs are available on the market for the treatment of PD. Nonetheless, these drugs show parasympathomimetic related adverse events and remarkably higher toxicity; hence, it is important to find more efficacious molecules to treat PD. In our study, We… More >

MARLA DE CERQUEIRA ALVES¹, MONISE OLIVEIRA SANTOS¹, NASSIB BEZERRA BUENO¹, ORLANDO ROBERTO PIMENTEL DE ARAÚJO², MARÍLIA OLIVEIRA FONSECA GOULART^2,3,4, FABIANA ANDRÉA MOURA^1,5,*

BIOCELL, Vol.46, No.9, pp. 2015-2047, 2022, DOI:10.32604/biocell.2022.020407 - 18 May 2022

Abstract

The roots of the vegetal Curcuma due to its high content of polyphenols, has been used successfully in several clinical situations. This review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease (IBD). A systematic review of animal models and randomized clinical trials (RCTs) was conducted by searching the following electronic databases: PubMed, CENTRAL, LILACS, Science Direct, and ClinicalTrials.gov. From 997 found records, 62 were included. More than 90% of the animal studies reported an improvement in macroscopic, histologic and/or functional activity; 80% identified decreased oxidative and/or inflammatory biomarkers in

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ABDELKADER HASSANI^1,2,3, SITI ASLINA HUSSAIN², MOTHANNA SADIQ AL-QUBAISI⁴, MOHAMED LAKHDER BELFAR³, HAKIM BELKHALFA⁵, HAMID HAMMAD ENEZEI⁶, HAMID ZENTOU², WISAM NABEEL IBRAHIM^7,8,*, ABD ALMONEM DOOLAANEA^1,*

BIOCELL, Vol.46, No.3, pp. 677-687, 2022, DOI:10.32604/biocell.2022.016848 - 18 November 2021

Abstract The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. More >

Xiang Zhou^*1, Weiming Wang^†1, Pihong Li^*, Zhiqiang Zheng^*, Yangyang Tu^*, Yi Zhang^*, Tao You^*

Oncology Research, Vol.23, No.1-2, pp. 29-34, 2015, DOI:10.3727/096504015X14452563486011

Abstract Despite the efficacy of fluoropyrimidines and oxaliplatin-based chemotherapy for patients, this treatment leads to significant patient inconvenience, toxicity, and cost. This study aims to validate a nontoxic agent, curcumin, to the current chemotherapeutic regimen. In in vitro experiments, curcumin induced apoptosis in gastric cancer cell line BGC-823. Synergistic antitumor effects of curcumin were observed in combination with 5-fluorouracil (5-FU) and oxaliplatin. These effects were accompanied by downregulation of the expression of Bcl-2 protein and mRNA and upregulation of the expression of Bax and caspase 3, 8, and 9. In addition, the in vivo study showed More >